| Literature DB >> 17253676 |
Franco Chimenti1, Elias Maccioni, Daniela Secci, Adriana Bolasco, Paola Chimenti, Arianna Granese, Olivia Befani, Paola Turini, Stefano Alcaro, Francesco Ortuso, Maria C Cardia, Simona Distinto.
Abstract
A series of 2-thiazolylhydrazone derivatives have been investigated for the ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO) selectively. All of the compounds showed high activity against both the MAO-A and the MAO-B isoforms with pKi values ranging between 5.92 and 8.14 for the MAO-A and between 4.69 and 9.09 for the MAO-B isoforms. Both the MAO-A and the MAO-B isoforms, deposited in the Protein Data Bank as model 2BXR and 1GOS, respectively, were considered in a computational study performed with docking techniques on the most active and MAO-B-selective inhibitor, 18.Entities:
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Year: 2007 PMID： 17253676 DOI： 10.1021/jm060869d
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446