Literature DB >> 17252499

Diterpenes and synthetic derivatives from Viguiera aspillioides with trypanomicidal activity.

F B da Costa1, S Albuquerque, W Vichnewski.   

Abstract

The dichloromethane extract of the tuberous roots of Viguiera aspillioides was tested in vitro against T. cruzi and then investigated in order to identify its active compounds, which were the known diterpenes (-)-ent-kaur-16-en-19-oic acid, (-)-trachyloban-19-oic acid, and (-)-kauran-16alpha-ol. Synthetic derivatives of the acidic compounds were obtained and tested; one of them, (-)-kaur-16-en-19-ol, was also active. Their IC50 are given.

Entities:  

Year:  1996        PMID： 17252499     DOI： 10.1055/s-2006-957971

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  7 in total

1.  Untargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase.

Authors:  Lucas A Chibli; Annylory L Rosa; Maria Cristina Nonato; Fernando B Da Costa
Journal:  Metabolomics       Date:  2019-04-04       Impact factor: 4.290

Review 2.  Occurrence, biological activities and synthesis of kaurane diterpenes and their glycosides.

Authors:  Pablo Anselmo García; Alaíde Braga de Oliveira; Ronan Batista
Journal:  Molecules       Date:  2007-03-13       Impact factor: 4.411

3.  Kaurenoic Acid Possesses Leishmanicidal Activity by Triggering a NLRP12/IL-1β/cNOS/NO Pathway.

Authors:  Milena Menegazzo Miranda; Carolina Panis; Suelen Santos da Silva; Juliana Aparecida Macri; Natalia Yoshie Kawakami; Thiago Hideki Hayashida; Tiago Bervelieri Madeira; Vinicius Ricardo Acquaro; Suzana Lucy Nixdorf; Luciana Pizzatti; Sérgio Ricardo Ambrósio; Rubens Cecchini; Nilton Syogo Arakawa; Waldiceu Aparecido Verri; Ivete Conchon Costa; Wander Rogério Pavanelli
Journal:  Mediators Inflamm       Date:  2015-05-13       Impact factor: 4.711

4.  Antimicrobial activity of diterpenes from Viguiera arenaria against endodontic bacteria.

Authors:  Tatiane C Carvalho; Marília R Simão; Sérgio R Ambrósio; Niege A J C Furtado; Rodrigo C S Veneziani; Vladimir C G Heleno; Fernando B Da Costa; Brenda P F A Gomes; Maria Gorete M Souza; Erika Borges dos Reis; Carlos H G Martins
Journal:  Molecules       Date:  2011-01-13       Impact factor: 4.411

5.  ent-Pimarane and ent-Kaurane Diterpenes from Aldama discolor (Asteraceae) and Their Antiprotozoal Activity.

Authors:  Mauro S Nogueira; Fernando B Da Costa; Reto Brun; Marcel Kaiser; Thomas J Schmidt
Journal:  Molecules       Date:  2016-09-15       Impact factor: 4.411

Review 6.  Porphyromonas gingivalis: where do we stand in our battle against this oral pathogen?

Authors:  Kaitlind C Howard; Octavio A Gonzalez; Sylvie Garneau-Tsodikova
Journal:  RSC Med Chem       Date:  2021-02-26

7.  Pimarane-type diterpenes: antimicrobial activity against oral pathogens.

Authors:  Thiago S Porto; Rander Rangel; Niege A J C Furtado; Tatiane C de Carvalho; Carlos H G Martins; Rodrigo C S Veneziani; Fernando B Da Costa; Adriana H C Vinholis; Wilson R Cunha; Vladimir C G Heleno; Sergio R Ambrosio
Journal:  Molecules       Date:  2009-01-04       Impact factor: 4.411
  7 in total

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