Literature DB >> 1723832

Demonstration of amyloid beta-protein in a 32-year-old man with progressive dementia.

D C Guiroy1, P P Liberski, J Alwasiak, W Papierz, D C Gajdusek.   

Abstract

We report the immunolocalization of extensive amyloid beta-protein in senile plaques, cerebrovascular amyloid deposits, neurofibrillary tangles and preamyloid in a 32-year-old man with progressive dementia not due to trisomy 21 or trauma. These amyloid deposits were non-reactive to antibodies directed against scrapie amyloid. Our data indicate that the presence of amyloid beta-protein is not limited to normal aging, Alzheimer's disease and related disorders but is also found in younger individuals with progressive dementia.

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Year:  1991        PMID： 1723832     DOI： 10.1007/bf00293389

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  17 in total

1.  Differential staining of acid glycosaminoglycans (mucopolysaccharides) by alcian blue in salt solutions.

Authors:  J E Scott; J Dorling
Journal:  Histochemie       Date:  1965-10-01

2.  Diagnosis of Creutzfeldt-Jakob disease by Western blot identification of marker protein in human brain tissue.

Authors:  P Brown; M Coker-Vann; K Pomeroy; M Franko; D M Asher; C J Gibbs; D C Gajdusek
Journal:  N Engl J Med       Date:  1986-02-27       Impact factor: 91.245

3.  Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein.

Authors:  F Coria; E M Castaño; B Frangione
Journal:  Am J Pathol       Date:  1987-12       Impact factor: 4.307

4.  Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.

Authors:  G G Glenner; C W Wong
Journal:  Biochem Biophys Res Commun       Date:  1984-05-16       Impact factor: 3.575

5.  Posttraumatic premature Alzheimer's disease. Neuropathologic findings and pathogenetic considerations.

Authors:  R Rudelli; J O Strom; P T Welch; M W Ambler
Journal:  Arch Neurol       Date:  1982-09

6.  Primary idiopathic cerebrovascular amyloidosis in a child.

Authors:  C M Shaw
Journal:  Brain       Date:  1979-03       Impact factor: 13.501

7.  Creutzfeldt-Jakob disease with plaques and paired helical filaments.

Authors:  P P Liberski; W Papierz; J Alwasiak
Journal:  Acta Neurol Scand       Date:  1987-12       Impact factor: 3.209

8.  Immunohistochemical study of cerebral amyloid angiopathy. II. Enhancement of immunostaining using formic acid pretreatment of tissue sections.

Authors:  H V Vinters; W M Pardridge; D L Secor; N Ishii
Journal:  Am J Pathol       Date:  1988-10       Impact factor: 4.307

9.  Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Authors:  C L Masters; G Simms; N A Weinman; G Multhaup; B L McDonald; K Beyreuther
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

10.  Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

Authors:  C L Masters; G Multhaup; G Simms; J Pottgiesser; R N Martins; K Beyreuther
Journal:  EMBO J       Date:  1985-11       Impact factor: 11.598
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  1 in total

1.  Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4- to 4.5-kilodalton protein which is immunoreactive to anti-amyloid beta/A4-protein antibodies.

Authors:  D C Guiroy; M Mellini; M Miyazaki; C Hilbich; J Safar; R M Garruto; R Yanagihara; K Beyreuther; D C Gajdusek
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088
  1 in total

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