OBJECTIVE: The aim of the present study was to evaluate serum concentrations of tumor necrosis factor-alpha (TNF-alpha), TNF-soluble receptors, and IL-6 in obese women without additional diseases and obese women with polycystic ovary syndrome (PCOS). STUDY DESIGN: The study group consisted of 39 obese women with PCOS and 34 age-matched obese women without additional disease were included as controls. Blood glucose, total cholesterol, HDL-cholesterol, and triglycerides were measured by the enzymatic procedure. Plasma insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS), androstenedione, total and free testosterone, cortisol, progesterone, 17OH-progesterone, estradiol, and sex hormone binding globulin (SHBG) were measured by a commercial radioimmunoassay (RIA). Tumor necrosis factor-alpha (TNF-alpha), soluble TNF receptors (sTNFRs), and IL-6 were determined by an ELISA. RESULTS: We did not observe any differences in serum concentrations of TNF-alpha between obese women with and without PCOS. Serum concentrations of sTNFR1 and sTNFR2 were significantly higher in PCOS patients compared with controls; however, serum concentrations of IL-6 were significantly lower in PCOS patients. CONCLUSIONS: Our findings suggest that PCOS is not associated with chronic inflammation.
OBJECTIVE: The aim of the present study was to evaluate serum concentrations of tumor necrosis factor-alpha (TNF-alpha), TNF-soluble receptors, and IL-6 in obesewomen without additional diseases and obesewomen with polycystic ovary syndrome (PCOS). STUDY DESIGN: The study group consisted of 39 obesewomen with PCOS and 34 age-matched obesewomen without additional disease were included as controls. Blood glucose, total cholesterol, HDL-cholesterol, and triglycerides were measured by the enzymatic procedure. Plasma insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS), androstenedione, total and free testosterone, cortisol, progesterone, 17OH-progesterone, estradiol, and sex hormone binding globulin (SHBG) were measured by a commercial radioimmunoassay (RIA). Tumor necrosis factor-alpha (TNF-alpha), soluble TNF receptors (sTNFRs), and IL-6 were determined by an ELISA. RESULTS: We did not observe any differences in serum concentrations of TNF-alpha between obesewomen with and without PCOS. Serum concentrations of sTNFR1 and sTNFR2 were significantly higher in PCOSpatients compared with controls; however, serum concentrations of IL-6 were significantly lower in PCOSpatients. CONCLUSIONS: Our findings suggest that PCOS is not associated with chronic inflammation.
Authors: Charleston W K Chiang; Ching-Ti Liu; Guillaume Lettre; Leslie A Lange; Neal W Jorgensen; Brendan J Keating; Sailaja Vedantam; Nora L Nock; Nora Franceschini; Alex P Reiner; Ellen W Demerath; Eric Boerwinkle; Jerome I Rotter; James G Wilson; Kari E North; George J Papanicolaou; L Adrienne Cupples; Joanne M Murabito; Joel N Hirschhorn Journal: Genetics Date: 2012-06-19 Impact factor: 4.562
Authors: Judit Tenk; Péter Mátrai; Péter Hegyi; Ildikó Rostás; András Garami; Imre Szabó; Margit Solymár; Erika Pétervári; József Czimmer; Katalin Márta; Alexandra Mikó; Nóra Füredi; Andrea Párniczky; Csaba Zsiborás; Márta Balaskó Journal: PLoS One Date: 2016-11-21 Impact factor: 3.240