Literature DB >> 17212389

Examination of the new alpha-(2'Z-fluoro)vinyl trigger with lysine decarboxylase: the absolute stereochemistry dictates the reaction course.

Kannan R Karukurichi1, Roberto de la Salud-Bea, Wan Jin Jahng, David B Berkowitz.   

Abstract

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Year:  2007        PMID： 17212389      PMCID： PMC2562574          DOI： 10.1021/ja067240k

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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  33 in total

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3.  A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation.

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4.  Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes.

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5.  Making chemistry selectable by linking it to infectivity.

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6.  Mechanism-based enzyme inactivators.

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7.  Mechanism-based cofactor derivatization of a copper amine oxidase by a branched primary amine recruits the oxidase activity of the enzyme to turn inactivator into substrate.

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Journal:  J Am Chem Soc       Date:  2006-05-10       Impact factor: 15.419

8.  Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography.

Authors:  Paola Storici; Jian Qiu; Tilman Schirmer; Richard B Silverman
Journal:  Biochemistry       Date:  2004-11-09       Impact factor: 3.162

9.  Inhibition of chymotrypsin by fluorinated alpha-keto acid derivatives.

Authors:  M F Parisi; R H Abeles
Journal:  Biochemistry       Date:  1992-10-06       Impact factor: 3.162

10.  Inhibition of tryptophan synthase by (1-fluorovinyl)glycine.

Authors:  Y Xu; R H Abeles
Journal:  Biochemistry       Date:  1993-01-26       Impact factor: 3.162
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4.  Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α-(1'-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators.

Authors:  Christopher D McCune; Matthew L Beio; Jill M Sturdivant; Roberto de la Salud-Bea; Brendan M Darnell; David B Berkowitz
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5.  S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit.

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7.  Use of Fluorinated Functionality in Enzyme Inhibitor Development: Mechanistic and Analytical Advantages.

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8.  "Zipped Synthesis" by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model.

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9.  A thiocyanopalladation/carbocyclization transformation identified through enzymatic screening: stereocontrolled tandem C-SCN and C-C bond formation.

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10.  Structural and functional analysis of the Francisella lysine decarboxylase as a key actor in oxidative stress resistance.

Authors:  Jan Felix; Claire Siebert; Julia Novion Ducassou; Jérôme Nigou; Pierre Simon Garcia; Angélique Fraudeau; Karine Huard; Caroline Mas; Céline Brochier-Armanet; Yohann Couté; Irina Gutsche; Patricia Renesto
Journal:  Sci Rep       Date:  2021-01-13       Impact factor: 4.379
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