Literature DB >> 17210764

High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae.

Nicole Wolter1, Anthony M Smith, Donald E Low, Keith P Klugman.   

Abstract

A rare clinical isolate of Streptococcus pneumoniae, highly resistant to telithromycin, contained erm(B) with a truncated leader peptide and a mutant ribosomal protein L4. By transformation of susceptible strains, this study shows that high-level telithromycin resistance is conferred by erm(B), wild type or mutant, in combination with a (69)GTG(71)-to-TPS mutation in ribosomal protein L4.

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Year:  2007        PMID： 17210764      PMCID： PMC1803110          DOI： 10.1128/AAC.01153-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  30 in total

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