Literature DB >> 16048973

Molecular characterization of the first telithromycin-resistant Streptococcus pneumoniae isolate in Germany.

Ralf René Reinert1, Mark van der Linden, Adnan Al-Lahham.   

Abstract

A total of 486 Streptococcus pneumoniae isolates were collected in 2003 and 2004 in Germany and revealed the following resistance rates: penicillin G (7.2%) and erythromycin A (18.9%). Telithromycin exhibited good in vitro activity (MIC at which 90% of the isolates tested were inhibited, 0.125 microg/ml). However, one erm(B)-positive isolate was found to be telithromycin resistant (MIC, 8 microg/ml).

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Year:  2005        PMID： 16048973      PMCID： PMC1196262          DOI： 10.1128/AAC.49.8.3520-3522.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients with respiratory tract infections in Germany from 1998 to 1999: results of a national surveillance study.

Authors:  R R Reinert; S Simic; A Al-Lahham; S Reinert; M Lemperle; R Lütticken
Journal:  J Clin Microbiol       Date:  2001-03       Impact factor: 5.948

2.  Phenotypic and molecular characterization of tetracycline- and erythromycin-resistant strains of Streptococcus pneumoniae.

Authors:  Maria P Montanari; Ileana Cochetti; Marina Mingoia; Pietro E Varaldo
Journal:  Antimicrob Agents Chemother       Date:  2003-07       Impact factor: 5.191

3.  Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae.

Authors:  Annie Canu; Brigitte Malbruny; Maëlle Coquemont; Todd A Davies; Peter C Appelbaum; Roland Leclercq
Journal:  Antimicrob Agents Chemother       Date:  2002-01       Impact factor: 5.191

4.  Emergence of macrolide and penicillin resistance among invasive pneumococcal isolates in Germany.

Authors:  Ralf René Reinert; Adnan Al-Lahham; Maria Lemperle; Christoph Tenholte; Claudia Briefs; Stefan Haupts; Hans Hubert Gerards; Rudolf Lütticken
Journal:  J Antimicrob Chemother       Date:  2002-01       Impact factor: 5.790

5.  Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage.

Authors:  A Tait-Kamradt; T Davies; M Cronan; M R Jacobs; P C Appelbaum; J Sutcliffe
Journal:  Antimicrob Agents Chemother       Date:  2000-08       Impact factor: 5.191

6.  Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and compatative in vitro activity of the ketolide, telithromycin.

Authors:  David Felmingham; Ralf Rene Reinert; Yoichi Hirakata; Arne Rodloff
Journal:  J Antimicrob Chemother       Date:  2002-09       Impact factor: 5.790

7.  Molecular epidemiology of macrolide-resistant Streptococcus pneumoniae isolates in Europe.

Authors:  Ralf René Reinert; Adrian Ringelstein; Mark van der Linden; Murat Yücel Cil; Adnan Al-Lahham; Franz-Josef Schmitz
Journal:  J Clin Microbiol       Date:  2005-03       Impact factor: 5.948

8.  Activities of telithromycin against 13,874 Streptococcus pneumoniae isolates collected between 1999 and 2003.

Authors:  David J Farrell; David Felmingham
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

Review 9.  Clinical efficacy of ketolides in the treatment of respiratory tract infections.

Authors:  Ralf René Reinert
Journal:  J Antimicrob Chemother       Date:  2004-04-29       Impact factor: 5.790

10.  Ribosomal mutations conferring resistance to macrolides in Streptococcus pneumoniae clinical strains isolated in Germany.

Authors:  Ralf René Reinert; Angela Wild; Peter Appelbaum; Rudolf Lütticken; Murat Yücel Cil; Adnan Al-Lahham
Journal:  Antimicrob Agents Chemother       Date:  2003-07       Impact factor: 5.191
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  13 in total

1.  Synthesis and structure-activity relationships of novel lincomycin derivatives. Part 2. Synthesis of 7(S)-7-deoxy-7-(4-morpholinocarbonylphenylthio)lincomycin and its 3-dimensional analysis with rRNA.

Authors:  Yoshinari Wakiyama; Ko Kumura; Eijiro Umemura; Satomi Masaki; Kazutaka Ueda; Takashi Watanabe; Mikio Yamamoto; Yoko Hirai; Keiichi Ajito
Journal:  J Antibiot (Tokyo)       Date:  2015-12-16       Impact factor: 2.649

2.  Streptococcus pneumoniae isolates resistant to telithromycin.

Authors:  M Rantala; M Haanperä-Heikkinen; M Lindgren; H Seppälä; P Huovinen; J Jalava
Journal:  Antimicrob Agents Chemother       Date:  2006-05       Impact factor: 5.191

3.  High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae.

Authors:  Nicole Wolter; Anthony M Smith; Donald E Low; Keith P Klugman
Journal:  Antimicrob Agents Chemother       Date:  2007-01-08       Impact factor: 5.191

4.  Antimicrobial susceptibility of invasive Streptococcus pneumoniae isolates in Portugal over an 11-year period.

Authors:  Ricardo Dias; Deolinda Louro; Manuela Caniça
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

5.  Trends in resistance to penicillin and erythromycin of invasive pneumococci in Portugal.

Authors:  R Dias; M Caniça
Journal:  Epidemiol Infect       Date:  2007-08-16       Impact factor: 2.451

6.  Synthesis and SARs of novel lincomycin derivatives Part 5: optimization of lincomycin analogs exhibiting potent antibacterial activities by chemical modification at the 6- and 7-positions.

Authors:  Yoshinari Wakiyama; Ko Kumura; Eijiro Umemura; Satomi Masaki; Kazutaka Ueda; Yasuo Sato; Yoko Hirai; Yoshio Hayashi; Keiichi Ajito
Journal:  J Antibiot (Tokyo)       Date:  2017-11-01       Impact factor: 2.649

7.  Synthesis and structure-activity relationships of novel lincomycin derivatives part 3: discovery of the 4-(pyrimidin-5-yl)phenyl group in synthesis of 7(S)-thiolincomycin analogs.

Authors:  Yoshinari Wakiyama; Ko Kumura; Eijiro Umemura; Satomi Masaki; Kazutaka Ueda; Yasuo Sato; Takashi Watanabe; Yoko Hirai; Keiichi Ajito
Journal:  J Antibiot (Tokyo)       Date:  2016-10-05       Impact factor: 2.649

8.  Synthesis and structure-activity relationships of novel lincomycin derivatives. Part 4: synthesis of novel lincomycin analogs modified at the 6- and 7-positions and their potent antibacterial activities.

Authors:  Yoshinari Wakiyama; Ko Kumura; Eijiro Umemura; Kazutaka Ueda; Takashi Watanabe; Keiko Yamada; Takafumi Okutomi; Keiichi Ajito
Journal:  J Antibiot (Tokyo)       Date:  2017-05-31       Impact factor: 2.649

Review 9.  Resistance to Macrolide Antibiotics in Public Health Pathogens.

Authors:  Corey Fyfe; Trudy H Grossman; Kathy Kerstein; Joyce Sutcliffe
Journal:  Cold Spring Harb Perspect Med       Date:  2016-10-03       Impact factor: 6.915

10.  Methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible.

Authors:  Akiko Takaya; Yoshiharu Sato; Tatsuma Shoji; Tomoko Yamamoto
Journal:  Antimicrob Agents Chemother       Date:  2013-05-28       Impact factor: 5.191
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