Literature DB >> 17206506

In vitro activity of perifosine: a novel alkylphospholipid against the promastigote stage of Leishmania species.

María Gabriela Cabrera-Serra1, Jacob Lorenzo-Morales, Marialina Romero, Basilio Valladares, José E Piñero.   

Abstract

Perifosine is a novel alkylphospholipid. Perifosine has displayed significant antiproliferative activity in vitro and in vivo in several human tumor model systems and has recently entered phase II clinical trials. Other alkylphospholipids have been previously used as antileishmanial agents, and miltefosine (Impavido) is now established as the first oral drug for the treatment of visceral and cutaneous leishmaniasis. Perifosine showed the higher activity against all tested strains. This study demonstrates for, the first time, an in vitro activity of perifosine against different species of Leishmania in the promastigote stage.

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Year:  2007        PMID： 17206506     DOI： 10.1007/s00436-006-0408-4

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  5 in total

Review 1.  Chemotherapy of trypanosomiases and leishmaniasis.

Authors:  Simon L Croft; Michael P Barrett; Julio A Urbina
Journal:  Trends Parasitol       Date:  2005-09-08

2.  Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH(3) (edelfosine) and amphotericin B.

Authors:  Patricia Escobar; Sangeeta Matu; Cláudia Marques; Simon L Croft
Journal:  Acta Trop       Date:  2002-02       Impact factor: 3.112

3.  Effect of the lysophospholipid analogues edelfosine, ilmofosine and miltefosine against Leishmania amazonensis.

Authors:  Ricardo M Santa-Rita; Andréa Henriques-Pons; Helene S Barbosa; Solange L de Castro
Journal:  J Antimicrob Chemother       Date:  2004-08-25       Impact factor: 5.790

4.  New administration model of trans-chalcone biodegradable polymers for the treatment of experimental leishmaniasis.

Authors:  Jose Piñero; Rosane M Temporal; Antonio J Silva-Gonçalves; I A Jiménez; Isabel L Bazzocchi; Alexis Oliva; Antonio Perera; Leonor L Leon; Basilio Valladares
Journal:  Acta Trop       Date:  2006-03-09       Impact factor: 3.112

5.  A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial.

Authors:  M Knowling; M Blackstein; R Tozer; V Bramwell; J Dancey; N Dore; S Matthews; E Eisenhauer
Journal:  Invest New Drugs       Date:  2006-09       Impact factor: 3.850
  5 in total
  10 in total

1.  Leishmanicidal activity of α-bisabolol from Tunisian chamomile essential oil.

Authors:  Soumaya Hajaji; Ines Sifaoui; Atteneri López-Arencibia; María Reyes-Batlle; Ignacio A Jiménez; Isabel L Bazzocchi; Basilio Valladares; Hafidh Akkari; Jacob Lorenzo-Morales; José E Piñero
Journal:  Parasitol Res       Date:  2018-06-28       Impact factor: 2.289

2.  Assessment of the antiprotozoal activity of Pulicaria inuloides extracts, an Algerian medicinal plant: leishmanicidal bioguided fractionation.

Authors:  Hamza Fadel; Ines Sifaoui; Atteneri López-Arencibia; María Reyes-Batlle; Soumaya Hajaji; Olfa Chiboub; Ignacio A Jiménez; Isabel L Bazzocchi; Jacob Lorenzo-Morales; Samir Benayache; José E Piñero
Journal:  Parasitol Res       Date:  2018-01-06       Impact factor: 2.289

3.  Perifosine Mechanisms of Action in Leishmania Species.

Authors:  Atteneri López-Arencibia; Carmen Martín-Navarro; Ines Sifaoui; María Reyes-Batlle; Carolina Wagner; Jacob Lorenzo-Morales; Sutherland K Maciver; José E Piñero
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

4.  In vitro activities of hexaazatrinaphthylenes against Leishmania spp.

Authors:  Atteneri López-Arencibia; Daniel García-Velázquez; Carmen M Martín-Navarro; Ines Sifaoui; María Reyes-Batlle; Jacob Lorenzo-Morales; Ángel Gutiérrez-Ravelo; José E Piñero
Journal:  Antimicrob Agents Chemother       Date:  2015-03-09       Impact factor: 5.191

5.  Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug.

Authors:  María P Sánchez-Cañete; Luís Carvalho; F Javier Pérez-Victoria; Francisco Gamarro; Santiago Castanys
Journal:  Antimicrob Agents Chemother       Date:  2009-02-02       Impact factor: 5.191

6.  Evaluation of the effect of miltefosine on Trichomonas vaginalis.

Authors:  Débora Afonso Silva Rocha; Ivone de Andrade Rosa; Wanderley de Souza; Marlene Benchimol
Journal:  Parasitol Res       Date:  2013-12-22       Impact factor: 2.289

7.  In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites.

Authors:  Rubén E Varela-M; Janny A Villa-Pulgarin; Edward Yepes; Ingrid Müller; Manuel Modolell; Diana L Muñoz; Sara M Robledo; Carlos E Muskus; Julio López-Abán; Antonio Muro; Iván D Vélez; Faustino Mollinedo
Journal:  PLoS Negl Trop Dis       Date:  2012-04-10

8.  Update in the treatment of cutaneous leishmaniasis.

Authors:  Sahar H Al-Natour
Journal:  J Family Community Med       Date:  2009-05

9.  Structure and Antiparasitic Activity Relationship of Alkylphosphocholine Analogues against Leishmania donovani.

Authors:  Humera Ahmed; Katharine C Carter; Roderick A M Williams
Journal:  Microorganisms       Date:  2020-07-24

10.  Carajurin Induces Apoptosis in Leishmania amazonensis Promastigotes through Reactive Oxygen Species Production and Mitochondrial Dysfunction.

Authors:  João Victor Silva-Silva; Carla J Moragas-Tellis; Maria S S Chagas; Paulo Victor R Souza; Davyson L Moreira; Daiana J Hardoim; Noemi N Taniwaki; Vanessa F A Costa; Alvaro L Bertho; Daniela Brondani; Eduardo Zapp; Aldo Sena de Oliveira; Kátia S Calabrese; Maria D Behrens; Fernando Almeida-Souza
Journal:  Pharmaceuticals (Basel)       Date:  2022-03-09
  10 in total

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