| Literature DB >> 11801222 |
Patricia Escobar1, Sangeeta Matu, Cláudia Marques, Simon L Croft.
Abstract
The sensitivities of both promastigote and amastigote stages of six species of Leishmania, L. donovani, L. major, L. tropica, L. aethiopica, L. mexicana and L. panamensis, were determined in vitro to the phospholipid drugs hexadecylphosphocholine (HPC, miltefosine) and ET-18-OCH(3) (edelfosine). In all assays L. donovani was the most sensitive species, with ED(50) values in the range of 0.12-1.32 microM against promastigotes and 1.2-4.6 microM against amastigotes. L. major was the least sensitive species in the majority of assays with ED(50) values for HPC in the range of 4.8-13.1 microM against promastigotes and for HPC and ET-18-OCH(3) in the range of 7.5-37.1 microM against amastigotes. Amphotericin B deoxycholate was used as the standard drug and gave submicromolar ED(50) values in all assays; L. mexicana was the least sensitive species to this drug.Entities:
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Year: 2002 PMID： 11801222 DOI： 10.1016/s0001-706x(01)00197-8
Source DB: PubMed Journal: Acta Trop ISSN： 0001-706X Impact factor: 3.112