Literature DB >> 28096161

Perifosine Mechanisms of Action in Leishmania Species.

Atteneri López-Arencibia1,2, Carmen Martín-Navarro2, Ines Sifaoui3, María Reyes-Batlle2, Carolina Wagner2,4, Jacob Lorenzo-Morales2, Sutherland K Maciver5, José E Piñero2.   

Abstract

Here the mechanism by which perifosine induced cell death in Leishmania donovani and Leishmania amazonensis is described. The drug reduced Leishmania mitochondrial membrane potential and decreased cellular ATP levels while increasing phosphatidylserine externalization. Perifosine did not increase membrane permeabilization. We also found that the drug inhibited the phosphorylation of Akt in the parasites. These results highlight the potential use of perifosine as an alternative to miltefosine against Leishmania.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Leishmania; activity; apoptosis-like; perifosine

Mesh：

Substances：

Year:  2017        PMID： 28096161      PMCID： PMC5365646          DOI： 10.1128/AAC.02127-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

Review 1.  Protozoan parasites: programmed cell death as a mechanism of parasitism.

Authors:  Iris Bruchhaus; Thomas Roeder; Annika Rennenberg; Volker T Heussler
Journal:  Trends Parasitol       Date:  2007-06-27

Review 2.  Drug resistance in leishmaniasis.

Authors:  Simon L Croft; Shyam Sundar; Alan H Fairlamb
Journal:  Clin Microbiol Rev       Date:  2006-01       Impact factor: 26.132

3.  Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes.

Authors:  Fernanda de Aquino Marinho; Keyla Cristiny da Silva Gonçalves; Selma Soares de Oliveira; Ana-Carolina de Siqueira Couto de Oliveira; Maria Bellio; Claudia Masini d'Avila-Levy; André Luis Souza dos Santos; Marta Helena Branquinha
Journal:  Mem Inst Oswaldo Cruz       Date:  2011-06       Impact factor: 2.743

Review 4.  Leishmaniasis: vaccine candidates and perspectives.

Authors:  Bhawana Singh; Shyam Sundar
Journal:  Vaccine       Date:  2012-04-01       Impact factor: 3.641

5.  In vitro effects of triterpenic acids from olive leaf extracts on the mitochondrial membrane potential of promastigote stage of Leishmania spp.

Authors:  Ines Sifaoui; Atteneri López-Arencibia; Carmen Maria Martín-Navarro; Juan Carlos Ticona; María Reyes-Batlle; Mondher Mejri; Antonio Ignacio Jiménez; Isabel Lopez-Bazzocchi; Basilio Valladares; Jacob Lorenzo-Morales; Manef Abderabba; José E Piñero
Journal:  Phytomedicine       Date:  2014-09-17       Impact factor: 5.340

6.  Therapeutic potential of a combination of two gene-specific small interfering RNAs against clinical strains of Acanthamoeba.

Authors:  Jacob Lorenzo-Morales; Carmen M Martín-Navarro; Atteneri López-Arencibia; María A Santana-Morales; Raquel N Afonso-Lehmann; Sutherland K Maciver; Basilio Valladares; Enrique Martínez-Carretero
Journal:  Antimicrob Agents Chemother       Date:  2010-09-20       Impact factor: 5.191

Review 7.  Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis.

Authors:  Thomas P C Dorlo; Manica Balasegaram; Jos H Beijnen; Peter J de Vries
Journal:  J Antimicrob Chemother       Date:  2012-07-24       Impact factor: 5.790

Review 8.  Current view on the mechanism of action of perifosine in cancer.

Authors:  Joachim Fensterle; Babette Aicher; Irene Seipelt; Michael Teifel; Juergen Engel
Journal:  Anticancer Agents Med Chem       Date:  2014-05       Impact factor: 2.505

9.  A parasite rescue and transformation assay for antileishmanial screening against intracellular Leishmania donovani amastigotes in THP1 human acute monocytic leukemia cell line.

Authors:  Surendra K Jain; Rajnish Sahu; Larry A Walker; Babu L Tekwani
Journal:  J Vis Exp       Date:  2012-12-30       Impact factor: 1.355

10.  Antileishmanial lead structures from nature: analysis of structure-activity relationships of a compound library derived from caffeic Acid bornyl ester.

Authors:  Jan Glaser; Martina Schultheis; Sudipta Hazra; Banasri Hazra; Heidrun Moll; Uta Schurigt; Ulrike Holzgrabe
Journal:  Molecules       Date:  2014-01-27       Impact factor: 4.411
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  7 in total

1.  Leishmanicidal activity of α-bisabolol from Tunisian chamomile essential oil.

Authors:  Soumaya Hajaji; Ines Sifaoui; Atteneri López-Arencibia; María Reyes-Batlle; Ignacio A Jiménez; Isabel L Bazzocchi; Basilio Valladares; Hafidh Akkari; Jacob Lorenzo-Morales; José E Piñero
Journal:  Parasitol Res       Date:  2018-06-28       Impact factor: 2.289

2.  Assessment of the antiprotozoal activity of Pulicaria inuloides extracts, an Algerian medicinal plant: leishmanicidal bioguided fractionation.

Authors:  Hamza Fadel; Ines Sifaoui; Atteneri López-Arencibia; María Reyes-Batlle; Soumaya Hajaji; Olfa Chiboub; Ignacio A Jiménez; Isabel L Bazzocchi; Jacob Lorenzo-Morales; Samir Benayache; José E Piñero
Journal:  Parasitol Res       Date:  2018-01-06       Impact factor: 2.289

3.  Discovery of Amoebicidal Compounds by Combining Computational and Experimental Approaches.

Authors:  Víctor Sebastián-Pérez; Ines Sifaoui; María Reyes-Batlle; Angélica Domínguez-De Barros; Atteneri López-Arencibia; Nuria E Campillo; José E Piñero; Jacob Lorenzo-Morales; Carmen Gil
Journal:  Antimicrob Agents Chemother       Date:  2021-01-20       Impact factor: 5.191

4.  In vitro activity of 1H-phenalen-1-one derivatives against Leishmania spp. and evidence of programmed cell death.

Authors:  Atteneri López-Arencibia; María Reyes-Batlle; Mónica B Freijo; Ines Sifaoui; Carlos J Bethencourt-Estrella; Aitor Rizo-Liendo; Olfa Chiboub; Grant McNaughton-Smith; Jacob Lorenzo-Morales; Teresa Abad-Grillo; José E Piñero
Journal:  Parasit Vectors       Date:  2019-12-23       Impact factor: 3.876

5.  In vitro and in vivo antileishmanial activity of β-acetyl-digitoxin, a cardenolide of Digitalis lanata potentially useful to treat visceral leishmaniasis.

Authors:  Camila S Freitas; Daniela P Lage; João A Oliveira-da-Silva; Rafaella R Costa; Débora V C Mendonça; Vívian T Martins; Thiago A R Reis; Luciana M R Antinarelli; Amanda S Machado; Grasiele S V Tavares; Fernanda F Ramos; Rory C F Brito; Fernanda Ludolf; Miguel A Chávez-Fumagalli; Bruno M Roatt; Gabriela S Ramos; Jennifer Munkert; Flaviano M Ottoni; Priscilla R V Campana; Mariana C Duarte; Denise U Gonçalves; Elaine S Coimbra; Fernão C Braga; Rodrigo M Pádua; Eduardo A F Coelho
Journal:  Parasite       Date:  2021-04-14       Impact factor: 3.000

6.  Acrylonitrile Derivatives against Trypanosoma cruzi: In Vitro Activity and Programmed Cell Death Study.

Authors:  Carlos J Bethencourt-Estrella; Samuel Delgado-Hernández; Atteneri López-Arencibia; Desirée San Nicolás-Hernández; Ines Sifaoui; David Tejedor; Fernando García-Tellado; Jacob Lorenzo-Morales; José E Piñero
Journal:  Pharmaceuticals (Basel)       Date:  2021-06-09

7.  Discovery of New Chemical Tools against Leishmania amazonensis via the MMV Pathogen Box.

Authors:  Atteneri López-Arencibia; Ines Sifaoui; María Reyes-Batlle; Carlos J Bethencourt-Estrella; Desirée San Nicolás-Hernández; Jacob Lorenzo-Morales; José E Piñero
Journal:  Pharmaceuticals (Basel)       Date:  2021-11-24
  7 in total

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