Literature DB >> 1720549

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

S Ziemin-van der Poel1, N R McCabe, H J Gill, R Espinosa, Y Patel, A Harden, P Rubinelli, S D Smith, M M LeBeau, J D Rowley.   

Abstract

Recurring chromosomal translocations involving chromosome 11, band q23, have been observed in acute lymphoid leukemias and especially in acute myeloid leukemias. We recently showed that breakpoints in four 11q23 translocations, t(4;11)(q21;q23), t(6;11)(q27;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13.3), were contained within a yeast artificial chromosome clone bearing the CD3D and CD3G gene loci. We have identified within the CD3 yeast artificial chromosome a transcription unit that spans the breakpoint junctions of the 4;11, 9;11, and 11;19 translocations, and we describe two other, related transcripts that are upregulated in the RS4;11 cell line. We have named this gene MLL (myeloid/lymphoid, or mixed-lineage, leukemia.

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Year:  1991        PMID： 1720549      PMCID： PMC53005          DOI： 10.1073/pnas.88.23.10735

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

1.  Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome.

Authors:  J D Rowley; M O Diaz; R Espinosa; Y D Patel; E van Melle; S Ziemin; P Taillon-Miller; P Lichter; G A Evans; J H Kersey
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

2.  Myeloid surface antigen-positive acute lymphoblastic leukemia (My+ ALL): immunophenotypic, ultrastructural, cytogenetic, and molecular characteristics.

Authors:  C C Childs; C Hirsch-Ginsberg; R S Walters; B S Andersson; J Reuben; J M Trujillo; A Cork; S A Stass; E J Freireich; T F Zipf
Journal:  Leukemia       Date:  1989-11       Impact factor: 11.528

3.  Long-term growth of malignant thymocytes in vitro.

Authors:  S D Smith; P McFall; R Morgan; M Link; F Hecht; M Cleary; J Sklar
Journal:  Blood       Date:  1989-06       Impact factor: 22.113

4.  Immunoglobulin chain gene rearrangements in a t(4;11) acute leukaemia with monocytoid blasts.

Authors:  B I Srivastava; J J Wright; A Bakhshi
Journal:  Br J Haematol       Date:  1986-06       Impact factor: 6.998

5.  Isolation of single-copy human genes from a library of yeast artificial chromosome clones.

Authors:  B H Brownstein; G A Silverman; R D Little; D T Burke; S J Korsmeyer; D Schlessinger; M V Olson
Journal:  Science       Date:  1989-06-16       Impact factor: 47.728

6.  Establishment of a Ph1-positive human cell line (BV173).

Authors:  L Pegoraro; L Matera; J Ritz; A Levis; A Palumbo; G Biagini
Journal:  J Natl Cancer Inst       Date:  1983-03       Impact factor: 13.506

7.  In vitro culture of leukemic cells in t(4;11) acute leukemia.

Authors:  R C Stong; J H Kersey
Journal:  Blood       Date:  1985-08       Impact factor: 22.113

8.  A physical linkage group in human chromosome band 11q23 covering a region implicated in leukocyte neoplasia.

Authors:  A Tunnacliffe; R S McGuire
Journal:  Genomics       Date:  1990-11       Impact factor: 5.736

9.  CD3G is within 200 kb of the leukemic t(4;11) translocation breakpoint.

Authors:  S Das; F E Cotter; B Gibbons; S Dhut; B D Young
Journal:  Genes Chromosomes Cancer       Date:  1991-01       Impact factor: 5.006

10.  Gene order, amplification, and rearrangement of chromosome band 11q23 in hematologic malignancies.

Authors:  J J Yunis; C Jones; M T Madden; D Lu; M G Mayer
Journal:  Genomics       Date:  1989-07       Impact factor: 5.736
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  140 in total

1.  MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25).

Authors:  M Osaka; J D Rowley; N J Zeleznik-Le
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-25       Impact factor: 11.205

Review 2.  The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.

Authors:  Ali Shilatifard
Journal:  Annu Rev Biochem       Date:  2012       Impact factor: 23.643

3.  Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.

Authors:  Bernd B Zeisig; Tom Milne; María-Paz García-Cuéllar; Silke Schreiner; Mary-Ellen Martin; Uta Fuchs; Arndt Borkhardt; Sumit K Chanda; John Walker; Richard Soden; Jay L Hess; Robert K Slany
Journal:  Mol Cell Biol       Date:  2004-01       Impact factor: 4.272

Review 4.  Mouse chromosome 9.

Authors:  D M Kingsley
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 5.  Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins.

Authors:  Alea A Mills
Journal:  Nat Rev Cancer       Date:  2010-10       Impact factor: 60.716

6.  MLL leukemia induction by genome editing of human CD34+ hematopoietic cells.

Authors:  Corina Buechele; Erin H Breese; Dominik Schneidawind; Chiou-Hong Lin; Johan Jeong; Jesus Duque-Afonso; Stephen H K Wong; Kevin S Smith; Robert S Negrin; Matthew Porteus; Michael L Cleary
Journal:  Blood       Date:  2015-08-26       Impact factor: 22.113

7.  Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

Authors:  Anna M Azarova; Yi Lisa Lyu; Chao-Po Lin; Yuan-Chin Tsai; Johnson Yiu-Nam Lau; James C Wang; Leroy F Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-19       Impact factor: 11.205

8.  Pseudo-rearrangement of the MLL gene at chromosome 11q23: a cautionary note on genotype analysis of leukaemia patients.

Authors:  M Stanulla; H J Schünemann; S Thandla; M L Brecher; P D Aplan
Journal:  Mol Pathol       Date:  1998-04

Review 9.  Molecular pathogenesis of MLL-associated leukemias.

Authors:  Mariko Eguchi; Minenori Eguchi-Ishimae; Mel Greaves
Journal:  Int J Hematol       Date:  2005-07       Impact factor: 2.490

10.  Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.

Authors:  Emma C Collins; Alexandre Appert; Linda Ariza-McNaughton; Richard Pannell; Yoshihiro Yamada; Terence H Rabbitts
Journal:  Mol Cell Biol       Date:  2002-10       Impact factor: 4.272
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