OBJECTIVE: To describe and explain the syndrome of HIV-associated cryptogenic liver disease in eight consecutive patients suffering from portal hypertension. METHODS: The study was undertaken at a liver disease centre in Paris and involved eight of 97 consecutive HIV-infected patients presenting abnormal liver function tests and/or symptomatic portal hypertension of unknown origin. Serology, pathology, and liver function tests were performed. RESULTS: A clear nodular architecture corresponding to nodular regenerative hyperplasia was observed in seven patients and suggested in one, based on the presence of sinusoidal dilatation in a clinical context of portal hypertension, without overt liver disease. CONCLUSIONS: Nodular regenerative hyperplasia appears to be a new cause of portal hypertension in HIV-infected patients. This syndrome can be of critical importance as patients can be exposed to the significant complications of portal hypertension and to refractory ascites which may require liver transplantation.
OBJECTIVE: To describe and explain the syndrome of HIV-associated cryptogenic liver disease in eight consecutive patients suffering from portal hypertension. METHODS: The study was undertaken at a liver disease centre in Paris and involved eight of 97 consecutive HIV-infectedpatients presenting abnormal liver function tests and/or symptomatic portal hypertension of unknown origin. Serology, pathology, and liver function tests were performed. RESULTS: A clear nodular architecture corresponding to nodular regenerative hyperplasia was observed in seven patients and suggested in one, based on the presence of sinusoidal dilatation in a clinical context of portal hypertension, without overt liver disease. CONCLUSIONS: Nodular regenerative hyperplasia appears to be a new cause of portal hypertension in HIV-infectedpatients. This syndrome can be of critical importance as patients can be exposed to the significant complications of portal hypertension and to refractory ascites which may require liver transplantation.
Authors: Helen Kovari; Caroline A Sabin; Bruno Ledergerber; Lene Ryom; Signe W Worm; Colette Smith; Andrew Phillips; Peter Reiss; Eric Fontas; Kathy Petoumenos; Stéphane De Wit; Philippe Morlat; Jens D Lundgren; Rainer Weber Journal: Clin Infect Dis Date: 2012-10-22 Impact factor: 9.079
Authors: Aída de Fátima Thomé Barbosa Gouvêa; Daisy Maria Machado; Suênia Cordeiro de Vasconcelos Beltrão; Fabiana Bononi do Carmo; Regina Helena Guedes Motta Mattar; Regina Célia de Menezes Succi Journal: Rev Paul Pediatr Date: 2015-03-27
Authors: Vatsalya Vatsalya; Matthew C Cave; Rajarshi Kumar; Shweta Srivastava; Sujita Khanal; Alfred B Jenson; Melanie L Schwandt; Shirish S Barve; Vijay A Ramchandani; Craig J McClain Journal: AIDS Res Hum Retroviruses Date: 2018-12-11 Impact factor: 2.205