Literature DB >> 17191682

Oxachelin, a novel iron chelator and antifungal agent from Streptomyces sp. GW9/1258.

Bernd Sontag1, Martin Gerlitz, Thomas Paululat, Hans-Falk Rasser, Iris Grün-Wollny, Friedrich G Hansske.   

Abstract

During a screening campaign for new antimicrobial and antifungal secondary metabolites from several thousand actinomycetes, a novel compound, isolated by activity guided fractionation, was oxachelin (1) from the new Streptomyces sp. GW9/1258. Oxachelin shows strong antibiotic activities against several fungi and Gram(+) bacteria. Additionally, oxachelin is a strong complexing ligand for Fe3+ (siderophore), possibly making it useful e.g. for iron excess diseases.

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Year:  2006        PMID： 17191682     DOI： 10.1038/ja.2006.88

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  11 in total

1.  Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate Streptomyces sp. RM-14-6.

Authors:  Khaled A Shaaban; Meredith A Saunders; Yinan Zhang; Tuan Tran; Sherif I Elshahawi; Larissa V Ponomareva; Xiachang Wang; Jianjun Zhang; Gregory C Copley; Manjula Sunkara; Madan K Kharel; Andrew J Morris; James C Hower; Matthew S Tremblay; Mark A Prendergast; Jon S Thorson
Journal:  J Nat Prod       Date:  2016-12-28       Impact factor: 4.050

2.  Identification of Neuroprotective Spoxazomicin and Oxachelin Glycosides via Chemoenzymatic Glycosyl-Scanning.

Authors:  Jianjun Zhang; Ryan R Hughes; Meredith A Saunders; Sherif I Elshahawi; Larissa V Ponomareva; Yinan Zhang; Sydney R Winchester; Samantha A Scott; Manjula Sunkara; Andrew J Morris; Mark A Prendergast; Khaled A Shaaban; Jon S Thorson
Journal:  J Nat Prod       Date:  2016-12-28       Impact factor: 4.050

3.  Bioweathering and biotransformation of granitic rock minerals by actinomycetes.

Authors:  Hesham Abdulla
Journal:  Microb Ecol       Date:  2009-07-10       Impact factor: 4.552

4.  Genome Mining and Metabolomics Unveil Pseudonochelin: A Siderophore Containing 5-Aminosalicylate from a Marine-Derived Pseudonocardia sp. Bacterium.

Authors:  Fan Zhang; René F Ramos Alvarenga; Kurt Throckmorton; Shaurya Chanana; Doug R Braun; Jen Fossen; Miao Zhao; Sue McCrone; Mary Kay Harper; Scott R Rajski; Warren E Rose; David R Andes; Michael G Thomas; Tim S Bugni
Journal:  Org Lett       Date:  2022-06-01       Impact factor: 6.072

5.  Conjugates of Iron-Transporting N-Hydroxylactams with Ciprofloxacin.

Authors:  Olga Bakulina; Anton Bannykh; Ekaterina Levashova; Mikhail Krasavin
Journal:  Molecules       Date:  2022-06-18       Impact factor: 4.927

6.  Gobichelin A and B: Mixed-Ligand Siderophores Discovered Using Proteomics.

Authors:  Yunqiu Chen; Michelle Unger; Ioanna Ntai; Ryan A McClure; Jessica C Albright; Regan J Thomson; Neil L Kelleher
Journal:  Medchemcomm       Date:  2012-09-24       Impact factor: 3.597

7.  Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4.

Authors:  Mohammad R Seyedsayamdost; Matthew F Traxler; Shao-Liang Zheng; Roberto Kolter; Jon Clardy
Journal:  J Am Chem Soc       Date:  2011-07-07       Impact factor: 15.419

8.  Catecholate siderophores protect bacteria from pyochelin toxicity.

Authors:  Conrado Adler; Natalia S Corbalán; Mohammad R Seyedsayamdost; María Fernanda Pomares; Ricardo E de Cristóbal; Jon Clardy; Roberto Kolter; Paula A Vincent
Journal:  PLoS One       Date:  2012-10-05       Impact factor: 3.240

9.  Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway.

Authors:  Sung Ryeol Park; Ashootosh Tripathi; Jianfeng Wu; Pamela J Schultz; Isaiah Yim; Thomas J McQuade; Fengan Yu; Carl-Johan Arevang; Abraham Y Mensah; Giselle Tamayo-Castillo; Chuanwu Xi; David H Sherman
Journal:  Nat Commun       Date:  2016-02-16       Impact factor: 14.919

10.  Genome Sequencing of Streptomyces atratus SCSIOZH16 and Activation Production of Nocardamine via Metabolic Engineering.

Authors:  Yan Li; Chunyan Zhang; Chengxiong Liu; Jianhua Ju; Junying Ma
Journal:  Front Microbiol       Date:  2018-06-13       Impact factor: 5.640
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