| Literature DB >> 35649263 |
Fan Zhang1, René F Ramos Alvarenga1, Kurt Throckmorton2, Shaurya Chanana1, Doug R Braun1, Jen Fossen3, Miao Zhao3, Sue McCrone4, Mary Kay Harper5, Scott R Rajski1, Warren E Rose4, David R Andes3, Michael G Thomas2, Tim S Bugni1.
Abstract
Pseudonochelin (1), a siderophore from a marine-derived Pseudonocardia sp. bacterium, was discovered using genome mining and metabolomics technologies. A 5-aminosalicylic acid (5-ASA) unit, not previously found in siderophore natural products, was identified in 1. Annotation of a putative psn biosynthetic gene cluster combined with bioinformatics and isotopic enrichment studies enabled us to propose the biosynthesis of 1. Moreover, 1 was found to display in vitro and in vivo antibacterial activity in an iron-dependent fashion.Entities:
Mesh：
Substances：
Year: 2022 PMID： 35649263 PMCID： PMC9270686 DOI： 10.1021/acs.orglett.2c01408
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.072