Literature DB >> 17189277

Testing the stand-alone microbeam at Columbia University.

G Garty1, G J Ross, A W Bigelow, G Randers-Pehrson, D J Brenner.   

Abstract

The stand-alone microbeam at Columbia University presents a novel approach to biological microbeam irradiation studies. Foregoing a conventional accelerator as a source of energetic ions, a small, high-specific-activity, alpha emitter is used. Alpha particles emitted from this source are focused using a compound magnetic lens consisting of 24 permanent magnets arranged in two quadrupole triplets. Using a 'home made' 6.5 mCi polonium source, a 1 alpha particle s(-1), 10 microm diameter microbeam can, in principle, be realised. As the alpha source energy is constant, once the microbeam has been set up, no further adjustments are necessary apart from a periodic replacement of the source. The use of permanent magnets eliminates the need for bulky power supplies and cooling systems required by other types of ion lenses and greatly simplifies operation. It also makes the microbeam simple and cheap enough to be realised in any large lab. The Microbeam design as well as first tests of its performance, using an accelerator-based beam are presented here.

Mesh:

Year:  2006        PMID: 17189277     DOI: 10.1093/rpd/ncl454

Source DB:  PubMed          Journal:  Radiat Prot Dosimetry        ISSN: 0144-8420            Impact factor:   0.972


  6 in total

1.  50 Years of the Radiological Research Accelerator Facility (RARAF).

Authors:  Stephen A Marino
Journal:  Radiat Res       Date:  2017-01-31       Impact factor: 2.841

2.  An ultrasoft X-ray multi-microbeam irradiation system for studies of DNA damage responses by fixed- and live-cell fluorescence microscopy.

Authors:  Carel van Oven; Przemek M Krawczyk; Jan Stap; Arline M Melo; Maria H O Piazzetta; Angelo L Gobbi; Henk A van Veen; Jan Verhoeven; Jacob A Aten
Journal:  Eur Biophys J       Date:  2009-06-03       Impact factor: 1.733

3.  Ion, X-ray, UV and Neutron Microbeam Systems for Cell Irradiation.

Authors:  A W Bigelow; G Randers-Pehrson; G Garty; C R Geard; Y Xu; A D Harken; G W Johnson; D J Brenner
Journal:  AIP Conf Proc       Date:  2010-08-08

4.  Microbeam irradiation of C. elegans nematode in microfluidic channels.

Authors:  M Buonanno; G Garty; M Grad; M Gendrel; O Hobert; D J Brenner
Journal:  Radiat Environ Biophys       Date:  2013-08-13       Impact factor: 1.925

5.  Design of a novel flow-and-shoot microbeam.

Authors:  G Garty; M Grad; B K Jones; Y Xu; J Xu; G Randers-Pehrson; D Attinger; D J Brenner
Journal:  Radiat Prot Dosimetry       Date:  2010-12-11       Impact factor: 0.972

6.  Automated microbeam observation environment for biological analysis-Custom portable environmental control applied to a vertical microbeam system.

Authors:  Matthew J England; Alan W Bigelow; Michael J Merchant; Eirini Velliou; David Welch; David J Brenner; Karen J Kirkby
Journal:  Sens Actuators B Chem       Date:  2016-08-16       Impact factor: 7.460

  6 in total

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