Literature DB >> 28140790

50 Years of the Radiological Research Accelerator Facility (RARAF).

Stephen A Marino1.   

Abstract

The Radiological Research Accelerator Facility (RARAF) is in its 50th year of operation. It was commissioned on April 1, 1967 as a collaboration between the Radiological Research Laboratory (RRL) of Columbia University, and members of the Medical Research Center of Brookhaven National Laboratory (BNL). It was initially funded as a user facility for radiobiology and radiological physics, concentrating on monoenergetic neutrons. Facilities for irradiation with MeV light charged particles were developed in the mid-1970s. In 1980 the facility was relocated to the Nevis Laboratories of Columbia University. RARAF now has seven beam lines, each having a dedicated irradiation facility: monoenergetic neutrons, charged particle track segments, two charged particle microbeams (one electrostatically focused to <1 μm, one magnetically focused), a 4.5 keV soft X-ray microbeam, a neutron microbeam, and a facility that produces a neutron spectrum similar to that of the atomic bomb dropped at Hiroshima. Biology facilities are available on site within close proximity to the irradiation facilities, making the RARAF very user friendly.

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Mesh:

Year:  2017        PMID: 28140790      PMCID: PMC5525045          DOI: 10.1667/RR002CC.1

Source DB:  PubMed          Journal:  Radiat Res        ISSN: 0033-7587            Impact factor:   2.841


  35 in total

1.  RBE as a function of neutron energy. I. Experimental observations.

Authors:  E J Hall; J K Novak; A M Kellerer; H H Rossi; S Marino; L J Goodman
Journal:  Radiat Res       Date:  1975-11       Impact factor: 2.841

2.  Integrated interdisciplinary training in the radiological sciences.

Authors:  D J Brenner; M Vazquez; M Buonanno; S A Amundson; A W Bigelow; G Garty; A D Harken; T K Hei; S A Marino; B Ponnaiya; G Randers-Pehrson; Y Xu
Journal:  Br J Radiol       Date:  2013-12-20       Impact factor: 3.039

3.  The Columbia University proton-induced soft x-ray microbeam.

Authors:  Andrew D Harken; Gerhard Randers-Pehrson; Gary W Johnson; David J Brenner
Journal:  Nucl Instrum Methods Phys Res B       Date:  2011-09-15       Impact factor: 1.377

4.  Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway.

Authors:  Hongning Zhou; Vladimir N Ivanov; Joseph Gillespie; Charles R Geard; Sally A Amundson; David J Brenner; Zengliang Yu; Howard B Lieberman; Tom K Hei
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-03       Impact factor: 11.205

5.  Mutations induced in Tradescantia by small doses of x-rays and neutrons: analysis of dose-Response curves.

Authors:  A H Sparrow; A G Underbrink; H H Rossi
Journal:  Science       Date:  1972-05-26       Impact factor: 47.728

6.  Neutron-energy-dependent oncogenic transformation of C3H 10T1/2 mouse cells.

Authors:  R C Miller; C R Geard; D J Brenner; K Komatsu; S A Marino; E J Hall
Journal:  Radiat Res       Date:  1989-01       Impact factor: 2.841

7.  Inactivation of synchronized Chinese Hamster V79 cells with charged-particle track segments.

Authors:  R P Bird; N Rohrig; R D Colvett; C R Geard; S A Marino
Journal:  Radiat Res       Date:  1980-05       Impact factor: 2.841

8.  A Mouse Ear Model for Bystander Studies Induced by Microbeam Irradiation.

Authors:  M Buonanno; G Randers-Pehrson; L B Smilenov; N J Kleiman; E Young; B Ponnayia; D J Brenner
Journal:  Radiat Res       Date:  2015-07-24       Impact factor: 2.841

9.  Regulation of early signaling and gene expression in the alpha-particle and bystander response of IMR-90 human fibroblasts.

Authors:  Shanaz A Ghandhi; Lihua Ming; Vladimir N Ivanov; Tom K Hei; Sally A Amundson
Journal:  BMC Med Genomics       Date:  2010-07-29       Impact factor: 3.063

Review 10.  Microbeam irradiation of the C. elegans nematode.

Authors:  Antonella Bertucci; Roger D J Pocock; Gerhard Randers-Pehrson; David J Brenner
Journal:  J Radiat Res       Date:  2009-03       Impact factor: 2.724

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  7 in total

1.  LET dependent response of GafChromic films investigated with MeV ion beams.

Authors:  V Grilj; D J Brenner
Journal:  Phys Med Biol       Date:  2018-12-18       Impact factor: 3.609

Review 2.  Focus small to find big - the microbeam story.

Authors:  Jinhua Wu; Tom K Hei
Journal:  Int J Radiat Biol       Date:  2017-08-29       Impact factor: 2.694

3.  Mitochondrial Damage Response and Fate of Normal Cells Exposed to FLASH Irradiation with Protons.

Authors:  Ziyang Guo; Manuela Buonanno; Andrew Harken; Guangming Zhou; Tom K Hei
Journal:  Radiat Res       Date:  2022-06-01       Impact factor: 3.372

4.  Traceable dosimetry for MeV ion beams.

Authors:  G Garty; A D Harken; D J Brenner
Journal:  J Instrum       Date:  2022-02-08       Impact factor: 1.121

5.  Predicting DNA damage foci and their experimental readout with 2D microscopy: a unified approach applied to photon and neutron exposures.

Authors:  Sofia Barbieri; Gabriele Babini; Jacopo Morini; Werner Friedland; Manuela Buonanno; Veljko Grilj; David J Brenner; Andrea Ottolenghi; Giorgio Baiocco
Journal:  Sci Rep       Date:  2019-09-30       Impact factor: 4.379

6.  An Integrated Preprocessing Approach for Exploring Single-Cell Gene Expression in Rare Cells.

Authors:  Junyi Shang; David Welch; Manuela Buonanno; Brian Ponnaiya; Guy Garty; Timothy Olsen; Sally A Amundson; Qiao Lin
Journal:  Sci Rep       Date:  2019-12-24       Impact factor: 4.379

Review 7.  Radiation-Induced Bystander Effect and Cytoplasmic Irradiation Studies with Microbeams.

Authors:  Ziqi Zhang; Kui Li; Mei Hong
Journal:  Biology (Basel)       Date:  2022-06-21
  7 in total

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