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Literature DB >> 17184948

Aging, B lymphopoiesis, and patterns of leukemogenesis.

Robert A J Signer¹, Encarnacion Montecino-Rodriguez, Kenneth Dorshkind.

Abstract

The production of B lymphocytes begins to decline steadily early in adult life and is severely compromised in the elderly. This occurrence has been attributed to intrinsic defects in early hematopoietic progenitors and B cell precursors as well as to microenvironmental changes in aged bone marrow. The aim of this review is to present an overview of B lymphocyte senescence and its underlying causes and to discuss its impact on immune function and leukemogenesis in aged individuals.

Mesh：

Year: 2006 PMID： 17184948 PMCID： PMC1924911 DOI： 10.1016/j.exger.2006.11.010

Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032

42 in total

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Journal: Nature Date: 2000-03-09 Impact factor: 49.962

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Journal: Immunity Date: 2002-08 Impact factor: 31.745

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Journal: Immunol Rev Date: 2002-11 Impact factor: 12.988

6. To T or not to T: reassessing the common lymphoid progenitor.

Authors: Encarnacion Montecino-Rodriguez; Kenneth Dorshkind
Journal: Nat Immunol Date: 2003-02 Impact factor: 25.606

7. The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors.

Authors: Juli P Miller; David Allman
Journal: J Immunol Date: 2003-09-01 Impact factor: 5.422

Review 8. Evolving patterns of lymphopoiesis from embryogenesis through senescence.

Authors: Encarnacion Montecino-Rodriguez; Kenneth Dorshkind
Journal: Immunity Date: 2006-06 Impact factor: 31.745

9. Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire.

Authors: Sara A Johnson; Stephen J Rozzo; John C Cambier
Journal: J Immunol Date: 2002-05-15 Impact factor: 5.422

10. Thymopoiesis independent of common lymphoid progenitors.

Authors: David Allman; Arivazhagan Sambandam; Sungjune Kim; Juli P Miller; Antonio Pagan; David Well; Anita Meraz; Avinash Bhandoola
Journal: Nat Immunol Date: 2003-01-06 Impact factor: 25.606

8 in total

1. Mechanistic insights into the impairment of memory B cells and antibody production in the elderly.

Authors: Judith H Aberle; Karin Stiasny; Michael Kundi; Franz X Heinz
Journal: Age (Dordr) Date: 2012-01-27

2. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia.

Authors: Robert A J Signer; Encarnacion Montecino-Rodriguez; Owen N Witte; Jami McLaughlin; Kenneth Dorshkind
Journal: Blood Date: 2007-06-06 Impact factor: 22.113

Review 3. Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil.

Authors: Lambert Busque; Manuel Buscarlet; Luigina Mollica; Ross L Levine
Journal: Stem Cells Date: 2018-06-08 Impact factor: 6.277

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Authors: B Grubeck-Loebenstein
Journal: Z Rheumatol Date: 2015-06 Impact factor: 1.372

5. Differences in mouse and human nonmemory B cell pools.

Authors: Abigail Benitez; Abby J Weldon; Lynnette Tatosyan; Vani Velkuru; Steve Lee; Terry-Ann Milford; Olivia L Francis; Sheri Hsu; Kavoos Nazeri; Carlos M Casiano; Rebekah Schneider; Jennifer Gonzalez; Rui-Jun Su; Ineavely Baez; Keith Colburn; Ioana Moldovan; Kimberly J Payne
Journal: J Immunol Date: 2014-04-09 Impact factor: 5.422