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Literature DB >> 12514733

Thymopoiesis independent of common lymphoid progenitors.

David Allman¹, Arivazhagan Sambandam, Sungjune Kim, Juli P Miller, Antonio Pagan, David Well, Anita Meraz, Avinash Bhandoola.

Abstract

Early T lineage progenitors (ETPs) in the thymus are thought to develop from common lymphoid progenitors (CLPs) in the bone marrow (BM). We compared thymic ETPs to BM CLPs in mice and found that they differed in several respects. Thymic ETPs were not interleukin 7 (IL-7)-responsive and generated B lineage progeny with delayed kinetics, whereas BM CLPs were IL-7-responsive and rapidly generated B cells. ETPs sustained production of T lineage progeny for longer periods of time than BM CLPs. Analysis of Ikaros-deficient mice that exhibit ongoing thymopoiesis without B lymphopoeisis revealed near-normal frequencies of thymic ETPs, yet undetectable numbers of BM CLPs. We conclude that ETPs can develop via a CLP-independent pathway.

Entities: Disease Gene Species

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Year: 2003 PMID： 12514733 DOI： 10.1038/ni878

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

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Cited

187 in total

1. Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors.

Authors: Barry Heavey; Christoforos Charalambous; Cesar Cobaleda; Meinrad Busslinger
Journal: EMBO J Date: 2003-08-01 Impact factor: 11.598

2. Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities.

Authors: Lei Nie; Min Xu; Antoaneta Vladimirova; Xiao-Hong Sun
Journal: EMBO J Date: 2003-11-03 Impact factor: 11.598

3. Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition.

Authors: Pablo Gómez-del Arco; Kazushige Maki; Katia Georgopoulos
Journal: Mol Cell Biol Date: 2004-04 Impact factor: 4.272

4. MCL1 increases primitive thymocyte viability in female mice and promotes thymic expansion into adulthood.

Authors: Jingang Gui; Amanda J Morales; Sophie E Maxey; Katherine A Bessette; Nora R Ratcliffe; John A Kelly; Ruth W Craig
Journal: Int Immunol Date: 2011-09-21 Impact factor: 4.823

5. Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

Authors: Todd D Ashworth; Warren S Pear; Mark Y Chiang; Stephen C Blacklow; Jérôme Mastio; Lanwei Xu; Michelle Kelliher; Philippe Kastner; Susan Chan; Jon C Aster
Journal: Blood Date: 2010-09-17 Impact factor: 22.113

Thymopoiesis independent of common lymphoid progenitors.

1. Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors.

2. Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities.

3. Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition.

4. MCL1 increases primitive thymocyte viability in female mice and promotes thymic expansion into adulthood.

5. Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

Review 6. Functional diversity of stem and progenitor cells with B-lymphopoietic potential.

7. T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage.

8. In vivo correction of ZAP-70 immunodeficiency by intrathymic gene transfer.

9. An overview of IL-7 biology and its use in immunotherapy.

Review 10. Transcriptional regulation of early B cell development.