Literature DB >> 1717995

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.

W Matthews1, C T Jordan, M Gavin, N A Jenkins, N G Copeland, I R Lemischka.   

Abstract

We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.

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Year:  1991        PMID： 1717995      PMCID： PMC52644          DOI： 10.1073/pnas.88.20.9026

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

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Authors:  O N Witte
Journal:  Cell       Date:  1990-10-05       Impact factor: 41.582

Review 2.  Development and applications of a molecular genetic linkage map of the mouse genome.

Authors:  N G Copeland; N A Jenkins
Journal:  Trends Genet       Date:  1991-04       Impact factor: 11.639

3.  A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations.

Authors:  W Matthews; C T Jordan; G W Wiegand; D Pardoll; I R Lemischka
Journal:  Cell       Date:  1991-06-28       Impact factor: 41.582

Review 4.  Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development.

Authors:  T Pawson; A Bernstein
Journal:  Trends Genet       Date:  1990-11       Impact factor: 11.639

5.  Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes.

Authors:  T Matsui; M Heidaran; T Miki; N Popescu; W La Rochelle; M Kraus; J Pierce; S Aaronson
Journal:  Science       Date:  1989-02-10       Impact factor: 47.728

6.  Patterns of amino acids near signal-sequence cleavage sites.

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Journal:  Eur J Biochem       Date:  1983-06-01

7.  Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

Authors:  K Nocka; S Majumder; B Chabot; P Ray; M Cervone; A Bernstein; P Besmer
Journal:  Genes Dev       Date:  1989-06       Impact factor: 11.361

8.  Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation.

Authors:  D A Stephenson; M Mercola; E Anderson; C Y Wang; C D Stiles; D F Bowen-Pope; V M Chapman
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-01       Impact factor: 11.205

9.  The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene.

Authors:  E N Geissler; M A Ryan; D E Housman
Journal:  Cell       Date:  1988-10-07       Impact factor: 41.582

10.  Developmental expression of c-kit, a proto-oncogene encoded by the W locus.

Authors:  A Orr-Urtreger; A Avivi; Y Zimmer; D Givol; Y Yarden; P Lonai
Journal:  Development       Date:  1990-08       Impact factor: 6.868
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  90 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-02       Impact factor: 11.205

Review 8.  Developmental relationship between hematopoietic and endothelial cells.

Authors:  Jesse J Lugus; Changwon Park; Kyunghee Choi
Journal:  Immunol Res       Date:  2005       Impact factor: 2.829

9.  CD133+ adult human retinal cells remain undifferentiated in Leukaemia Inhibitory Factor (LIF).

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Journal:  BMC Ophthalmol       Date:  2009-02-23       Impact factor: 2.209

10.  Flk-1, a receptor for vascular endothelial growth factor (VEGF), is expressed by retinal progenitor cells.

Authors:  X Yang; C L Cepko
Journal:  J Neurosci       Date:  1996-10-01       Impact factor: 6.167
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