| Literature DB >> 1648448 |
W Matthews1, C T Jordan, G W Wiegand, D Pardoll, I R Lemischka.
Abstract
To elucidate the molecular biology of the hematopoietic stem cell, we have begun to isolate genes from murine cell populations enriched in stem cell activity. One such cDNA encodes a novel receptor tyrosine kinase, designated fetal liver kinase-2 or flk-2, which is related to the W locus gene product c-kit. Expression analyses suggest an extremely restricted distribution of flk-2. It is expressed in populations enriched for stem cells and primitive uncommitted progenitors, and is absent in populations containing more mature cells. Therefore, this receptor may be a key signal transducing component in the totipotent hematopoietic stem cell and its immediate self-renewing progeny.Entities:
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Year: 1991 PMID： 1648448 DOI： 10.1016/0092-8674(91)90010-v
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582