Literature DB >> 17178801

Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii.

Aaron T Smith1, Meredith R Livingston, Antonello Mai, Patrizia Filetici, Sherry F Queener, William J Sullivan.   

Abstract

We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast.

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Year:  2006        PMID： 17178801      PMCID： PMC1803115          DOI： 10.1128/AAC.01256-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

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Review 4.  Toxoplasma histone acetylation remodelers as novel drug targets.

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Review 5.  A Systematic Review of In vitro and In vivo Activities of Anti-Toxoplasma Drugs and Compounds (2006-2016).

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  6 in total

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