| Literature DB >> 17178497 |
Yoshihiro Abiko1, Hiroki Nagayasu, Maiko Takeshima, Mami Yamazaki, Michiko Nishimura, Kaoru Kusano, Hiroyuki Kitajo, Masato Saitoh, Tomofumi Kawakami, Itsuo Chiba, Tohru Kaku.
Abstract
Ameloblastic carcinoma is described in the updated World Health Organization (WHO) classification as a rare malignant lesion. Ameloblastic carcinoma meeting the WHO criteria may arise either as a result of malignant change in a pre-existing benign ameloblastoma (carcinoma ex ameloblastoma) or as a primary malignant ameloblastoma not preceded by an ordinary ameloblastoma (de novo carcinoma). We report a case of ameloblastic carcinoma ex ameloblastoma and examine how this case underwent malignant transformation. The DNA was extracted separately from benign and malignant areas in paraffin sections of the tumor. Direct sequencing showed no genetic mutation of exons 5-8 of the p53 gene. Hypermethylation of CpG islands of the p16 gene was detected in the malignant parts of the tumor. The results indicate that hypermethylation of p16 may have been involved in the malignant transformation of the ameloblastoma in the present case.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17178497 DOI： 10.1016/j.tripleo.2006.01.021
Source DB: PubMed Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod ISSN： 1079-2104