Erison-Santana Santos1, Carla-Isabelly Rodrigues-Fernandes1, Joab-Cabral Cabral1, Felipe-Paiva Fonseca2, Adriana-Franco-Paes Leme3. 1. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. 2. Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. 3. Brazilian Biosciences National Laboratory, The Brazilian Center for Research in Energy and Materials, Campinas, Brazil.
Abstract
BACKGROUND: Ameloblastoma is a locally aggressive tumor, originated from odontogenic epithelium, and affects the jawbones with an elevated recurrence rate. The molecular mechanisms involved with the pathogenesis of this tumor remain undetermined. This review aimed to describe the current data regarding epigenetic alterations in ameloblastoma. MATERIAL AND METHODS: A systematized electronic search was performed in the English-language literature in three databases, combining the following keywords: ameloblastoma, epigenetic, methylation, noncoding RNA, histone acetylation. RESULTS: According to the gathered results of 11 studies in this review, epigenetic alterations could induce the development and progression of ameloblastoma. DNA methylation has been the most assessed mechanism in ameloblastomas. CONCLUSIONS: Current literature data indicate that epigenetic events can be involved in the etiopathogenesis of ameloblastomas. Key words:Ameloblastoma, epigenetic, methylation, noncoding RNA, histone acetylation. Copyright:
BACKGROUND: Ameloblastoma is a locally aggressive tumor, originated from odontogenic epithelium, and affects the jawbones with an elevated recurrence rate. The molecular mechanisms involved with the pathogenesis of this tumor remain undetermined. This review aimed to describe the current data regarding epigenetic alterations in ameloblastoma. MATERIAL AND METHODS: A systematized electronic search was performed in the English-language literature in three databases, combining the following keywords: ameloblastoma, epigenetic, methylation, noncoding RNA, histone acetylation. RESULTS: According to the gathered results of 11 studies in this review, epigenetic alterations could induce the development and progression of ameloblastoma. DNA methylation has been the most assessed mechanism in ameloblastomas. CONCLUSIONS: Current literature data indicate that epigenetic events can be involved in the etiopathogenesis of ameloblastomas. Key words:Ameloblastoma, epigenetic, methylation, noncoding RNA, histone acetylation. Copyright:
Authors: Fabrício F Costa; Valeria A Paixão; Felicia P Cavalher; Karina B Ribeiro; Isabela W Cunha; José Augusto Rinck; Michael O'Hare; Alan Mackay; Fernando A Soares; Ricardo R Brentani; Anamaria A Camargo Journal: Cancer Genet Cytogenet Date: 2006-03