| Literature DB >> 17178227 |
Ravindra K Rawal1, Rajkamal Tripathi, S B Katti, Christophe Pannecouque, Erik De Clercq.
Abstract
Compounds having isothiourea or thiourea functional group have shown high anti-HIV-1 activity. Therefore, a series of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones were designed, synthesized, and evaluated for anti-HIV-1 RT activity. The results of in vitro tests showed that the compound 9 exhibited EC50 at 0.26 microM with minimal toxicity in MT-4 cells as compared to 0.35 microM for thiazobenzimidazole (TBZ). It may be inferred from the present data that majority of compounds in this series exhibit higher selectivity index than TBZ.Entities:
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Year: 2006 PMID： 17178227 DOI： 10.1016/j.bmc.2006.12.003
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641