| Literature DB >> 17170732 |
J H J M van Krieken1, A W Langerak, E A Macintyre, M Kneba, E Hodges, R Garcia Sanz, G J Morgan, A Parreira, T J Molina, J Cabeçadas, P Gaulard, B Jasani, J F Garcia, M Ott, M L Hannsmann, F Berger, M Hummel, F Davi, M Brüggemann, F L Lavender, E Schuuring, P A S Evans, H White, G Salles, P J T A Groenen, P Gameiro, Ch Pott, J J M van Dongen.
Abstract
The diagnosis of malignant lymphoma is a recognized difficult area in histopathology. Therefore, detection of clonality in a suspected lymphoproliferation is a valuable diagnostic criterion. We have developed primer sets for the detection of rearrangements in the B- and T-cell receptor genes as reliable tools for clonality assessment in lymphoproliferations suspected for lymphoma. In this issue of Leukemia, the participants of the BIOMED-2 Concerted Action CT98-3936 report on the validation of the newly developed clonality assays in various disease entities. Clonality was detected in 99% of all B-cell malignancies and in 94% of all T-cell malignancies, whereas the great majority of reactive lesions showed polyclonality. The combined BIOMED-2 results are summarized in a guideline, which can now be implemented in routine lymphoma diagnostics. The use of this standardized approach in patients with a suspect lymphoproliferation will result in improved diagnosis of malignant lymphoma.Entities:
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Year: 2006 PMID： 17170732 DOI： 10.1038/sj.leu.2404467
Source DB: PubMed Journal: Leukemia ISSN： 0887-6924 Impact factor: 11.528