| Literature DB >> 17170255 |
Kitai Kim1, Paul Lerou, Akiko Yabuuchi, Claudia Lengerke, Kitwa Ng, Jason West, Andrew Kirby, Mark J Daly, George Q Daley.
Abstract
Genetically matched pluripotent embryonic stem (ES) cells generated via nuclear transfer or parthenogenesis (pES cells) are a potential source of histocompatible cells and tissues for transplantation. After parthenogenetic activation of murine oocytes and interruption of meiosis I or II, we isolated and genotyped pES cells and characterized those that carried the full complement of major histocompatibility complex (MHC) antigens of the oocyte donor. Differentiated tissues from these pES cells engrafted in immunocompetent MHC-matched mouse recipients, demonstrating that selected pES cells can serve as a source of histocompatible tissues for transplantation.Entities:
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Year: 2006 PMID: 17170255 DOI: 10.1126/science.1133542
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728