| Literature DB >> 17169327 |
John M Busillo1, Jeffrey L Benovic.
Abstract
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors, and is directly involved in a number of biological processes including organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome. Importantly, the involvement of CXCR4 in cancer metastasis and WHIM syndrome appears to be due to dysregulation of the receptor leading to enhanced signaling. Herein we review what is currently known regarding the regulation of CXCR4 and how dysregulation contributes to disease progression.Entities:
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Year: 2006 PMID： 17169327 PMCID： PMC1952230 DOI： 10.1016/j.bbamem.2006.11.002
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002