Literature DB >> 22453093

7th annual European Antibody Congress 2011: November 29-December 1, 2011, Geneva, Switzerland.

Alexey A Lugovskoy1, Janice M Reichert2, Alain Beck3.   

Abstract

The 7th European Antibody Congress (EAC), organized by Terrapin Ltd., was again held in Geneva, Switzerland, following on the tradition established with the 4th EAC. The 2011 version of the EAC was attended by nearly 250 delegates who learned of the latest advances and trends in the global development of antibody-based therapeutics. The first day focused on advances in understanding structure-function relationships, choosing the best format, glycoengineering biobetter antibodies, improving the efficacy and drugability of mAbs and epitope mapping. On the second day, the discovery of novel targets for mAb therapy, clinical pipeline updates, use of antibody combinations to address resistance, generation and identification of mAbs against new targets and biosimilar mAb development were discussed. Antibody-drug conjugates, domain antibodies and new scaffolds and bispecific antibodies were the topics of the third day. In total, nearly 50 speakers provided updates of programs related to antibody research and development on-going in the academic, government and commercial sectors.

Entities:  

Keywords:  antibody-drug conjugates; biosimilar antibodies; bispecific antibodies; protein scaffolds; therapeutic antibodies

Mesh:

Substances:

Year:  2012        PMID: 22453093      PMCID: PMC3361652          DOI: 10.4161/mabs.4.2.19426

Source DB:  PubMed          Journal:  MAbs        ISSN: 1942-0862            Impact factor:   5.857


  91 in total

1.  Comparison of the in vitro effects of the anti-CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells.

Authors:  Michaela Patz; Polina Isaeva; Nche Forcob; Bianka Müller; Lukas P Frenzel; Clemens-Martin Wendtner; Christian Klein; Pablo Umana; Michael Hallek; Günter Krause
Journal:  Br J Haematol       Date:  2010-12-13       Impact factor: 6.998

2.  The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20.

Authors:  Jessica L Teeling; Wendy J M Mackus; Luus J J M Wiegman; Jeroen H N van den Brakel; Stephen A Beers; Ruth R French; Tom van Meerten; Saskia Ebeling; Tom Vink; Jerry W Slootstra; Paul W H I Parren; Martin J Glennie; Jan G J van de Winkel
Journal:  J Immunol       Date:  2006-07-01       Impact factor: 5.422

3.  Local immune regulation in the central nervous system by substance P vs. glutamate.

Authors:  L P McCluskey; L A Lampson
Journal:  J Neuroimmunol       Date:  2001-06-01       Impact factor: 3.478

4.  Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer.

Authors:  Teemu T Junttila; Kathryn Parsons; Christine Olsson; Yanmei Lu; Yan Xin; Julie Theriault; Lisa Crocker; Oliver Pabonan; Tomasz Baginski; Gloria Meng; Klara Totpal; Robert F Kelley; Mark X Sliwkowski
Journal:  Cancer Res       Date:  2010-05-18       Impact factor: 12.701

5.  Antitumor efficacy of a thrombospondin 1 mimetic CovX-body.

Authors:  Lingna Li; Tom A Leedom; Janet Do; Hanhua Huang; JingYu Lai; Kim Johnson; Trina F Osothprarop; John D Rizzo; Venkata R Doppalapudi; Curt W Bradshaw; Rodney W Lappe; Gary Woodnutt; Nancy J Levin; Steven R Pirie-Shepherd
Journal:  Transl Oncol       Date:  2011-08-01       Impact factor: 4.243

6.  Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing.

Authors:  Stefan Lohse; Stefanie Derer; Thomas Beyer; Katja Klausz; Matthias Peipp; Jeanette H W Leusen; Jan G J van de Winkel; Michael Dechant; Thomas Valerius
Journal:  J Immunol       Date:  2011-02-11       Impact factor: 5.422

7.  Chemical generation of bispecific antibodies.

Authors:  Venkata R Doppalapudi; Jie Huang; Dingguo Liu; Ping Jin; Bin Liu; Lingna Li; Joel Desharnais; Crystal Hagen; Nancy J Levin; Michael J Shields; Michelle Parish; Robert E Murphy; Joselyn Del Rosario; Bryan D Oates; Jing-Yu Lai; Marla J Matin; Zemeda Ainekulu; Abhijit Bhat; Curt W Bradshaw; Gary Woodnutt; Richard A Lerner; Rodney W Lappe
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-13       Impact factor: 11.205

8.  Enhanced antibody half-life improves in vivo activity.

Authors:  Jonathan Zalevsky; Aaron K Chamberlain; Holly M Horton; Sher Karki; Irene W L Leung; Thomas J Sproule; Greg A Lazar; Derry C Roopenian; John R Desjarlais
Journal:  Nat Biotechnol       Date:  2010-01-17       Impact factor: 54.908

9.  Chimeric IgA antibodies against HLA class II effectively trigger lymphoma cell killing.

Authors:  Michael Dechant; Gestur Vidarsson; Bernhard Stockmeyer; Roland Repp; Martin J Glennie; Martin Gramatzki; Jan G J van De Winkel; Thomas Valerius
Journal:  Blood       Date:  2002-08-08       Impact factor: 22.113

Review 10.  Monoclonal antibodies in neuro-oncology: Getting past the blood-brain barrier.

Authors:  Lois A Lampson
Journal:  MAbs       Date:  2011-03-01       Impact factor: 5.857

View more
  4 in total

1.  Mabs's communication networks.

Authors:  Janice M Reichert
Journal:  MAbs       Date:  2012-03-01       Impact factor: 5.857

2.  Antibody-drug conjugates: present and future.

Authors:  Alain Beck; Janice M Reichert
Journal:  MAbs       Date:  2014 Jan-Feb       Impact factor: 5.857

3.  Marketing approval of mogamulizumab: a triumph for glyco-engineering.

Authors:  Alain Beck; Janice M Reichert
Journal:  MAbs       Date:  2012-07-01       Impact factor: 5.857

4.  Fourth World Antibody-Drug Conjugate Summit: February 29-March 1, 2012, Frankfurt, Germany.

Authors:  Alain Beck; John Lambert; Michael Sun; Kedan Lin
Journal:  MAbs       Date:  2012-08-22       Impact factor: 5.857

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.