BACKGROUND:Coronary heart disease (CHD) risk factors increase with age and body mass index (BMI; in kg/m2). However, whether lifestyle intervention ameliorates metabolic CHD risk factors in obese older adults is unknown. OBJECTIVE: The objective was to determine whether lifestyle intervention improves metabolic CHD risk factors in obese older adults. DESIGN: A 6-mo outpatient randomized controlled trial was conducted in obese (BMI >or= 30) older (>or=65 y) adults randomly assigned todiet and exercise therapy (treatment group; n = 17) or no therapy (control group; n = 10). The main outcomes were CHD risk factors. RESULTS:Body weight decreased by 8.4% (8.2 kg) in the treatment group; weight did not change significantly (0.7 kg) in the control group (P < 0.001 between groups). Changes between the control and treatment groups, respectively, in waist circumference (1 and -10 cm), plasma glucose (4 and -4 mg/dL), serum triacylglycerols (0 and -45 mg/dL), and systolic (-2 and -10 mm Hg) and diastolic (0 and -8 mm Hg) blood pressure were different (P < 0.05 for all). The number of subjects with the metabolic syndrome decreased by 59% in the treatment group but did not change significantly in the control group (P < 0.05). Serum free fatty acids increased by 10 micromol/L in the control group and decreased by 99 micromol/L in the treatment group (P < 0.05). Changes between the control and treatment groups, respectively, in C-reactive protein (0.8 and -2.5 mg/L) and interleukin 6 (1.6 and -2.4 pg/mL) were different (P < 0.05 for both). CONCLUSIONS:Lifestyle intervention decreases multiple metabolic CHD risk factors simultaneously in obese older adults.
RCT Entities:
BACKGROUND:Coronary heart disease (CHD) risk factors increase with age and body mass index (BMI; in kg/m2). However, whether lifestyle intervention ameliorates metabolic CHD risk factors in obese older adults is unknown. OBJECTIVE: The objective was to determine whether lifestyle intervention improves metabolic CHD risk factors in obese older adults. DESIGN: A 6-mo outpatient randomized controlled trial was conducted in obese (BMI >or= 30) older (>or=65 y) adults randomly assigned to diet and exercise therapy (treatment group; n = 17) or no therapy (control group; n = 10). The main outcomes were CHD risk factors. RESULTS: Body weight decreased by 8.4% (8.2 kg) in the treatment group; weight did not change significantly (0.7 kg) in the control group (P < 0.001 between groups). Changes between the control and treatment groups, respectively, in waist circumference (1 and -10 cm), plasma glucose (4 and -4 mg/dL), serum triacylglycerols (0 and -45 mg/dL), and systolic (-2 and -10 mm Hg) and diastolic (0 and -8 mm Hg) blood pressure were different (P < 0.05 for all). The number of subjects with the metabolic syndrome decreased by 59% in the treatment group but did not change significantly in the control group (P < 0.05). Serum free fatty acids increased by 10 micromol/L in the control group and decreased by 99 micromol/L in the treatment group (P < 0.05). Changes between the control and treatment groups, respectively, in C-reactive protein (0.8 and -2.5 mg/L) and interleukin 6 (1.6 and -2.4 pg/mL) were different (P < 0.05 for both). CONCLUSIONS: Lifestyle intervention decreases multiple metabolic CHD risk factors simultaneously in obese older adults.
Authors: L T Ptomey; E A Willis; J R Goetz; J Lee; A N Szabo-Reed; D K Sullivan; J E Donnelly Journal: J Hum Nutr Diet Date: 2015-02-09 Impact factor: 3.089
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Authors: M Kyla Shea; Denise K Houston; Barbara J Nicklas; Stephen P Messier; Cralen C Davis; Michael E Miller; Tamara B Harris; Dalane W Kitzman; Kimberly Kennedy; Stephen B Kritchevsky Journal: J Gerontol A Biol Sci Med Sci Date: 2010-01-15 Impact factor: 6.053
Authors: Steven K Malin; Nicole Niemi; Thomas P J Solomon; Jacob M Haus; Karen R Kelly; Julianne Filion; Michael Rocco; Sangeeta R Kashyap; Hope Barkoukis; John P Kirwan Journal: Ann Nutr Metab Date: 2012 Impact factor: 3.374
Authors: Dennis T Villareal; Marian R Banks; Bruce W Patterson; Kenneth S Polonsky; Samuel Klein Journal: Obesity (Silver Spring) Date: 2008-04-03 Impact factor: 5.002