PURPOSE: To investigate whether correction for atypical birefringence pattern (ABP) using scanning laser polarimetry with enhanced corneal compensation (SLP-ECC) reduces the severity of ABP compared with variable corneal compensation (SLP-VCC) and improves the correlation with visual function. DESIGN: Prospective observational study. METHODS: Normal and glaucomatous eyes enrolled from four clinical sites underwent complete examination, automated perimetry, SLP-ECC, and SLP-VCC. Eyes were characterized in three groups based upon the typical scan score (TSS): normal birefringence pattern (NBP) was defined as TSS > or = 80, mild ABP as TSS 61 to 79, and moderate-severe ABP as TSS < or = 60. For each of four SLP parameters, the area under the ROC curve (AUROC) was calculated to compare the ability of SLP-ECC and SLP-VCC to discriminate between normal and glaucomatous eyes. RESULTS: Eighty-four normal volunteers and 45 glaucoma patients were enrolled. Mean TSS was significantly (P < .001) greater using SLP-ECC (98.0 +/- 6.6) compared with SLP-VCC (83.4 +/- 22.5). The frequency of moderate-severe ABP images was significantly (P < .001, McNemar test) higher using SLP-VCC (18 of 129, 14%) compared with SLP-ECC (one of 129, 0.8%). Two SLP-ECC parameters (temporal superior nasal inferior temporal [TSNIT] average and inferior average) had significantly (P = .01, P < .001) higher correlation (r = .45, r = .50, respectively) with MD compared with SLP-VCC (r = .34, r = .37). Among eyes with moderate-severe ABP (n = 18), inferior average obtained using SLP-ECC had significantly (P = .03) greater AUROC (0.91 +/- 0.07) compared with SLP-VCC (0.78 +/- 0.11). CONCLUSIONS: SLP-ECC significantly reduces the frequency and severity of ABP compared with SLP-VCC and improves the correlation between RNFL measures and visual function.
PURPOSE: To investigate whether correction for atypical birefringence pattern (ABP) using scanning laser polarimetry with enhanced corneal compensation (SLP-ECC) reduces the severity of ABP compared with variable corneal compensation (SLP-VCC) and improves the correlation with visual function. DESIGN: Prospective observational study. METHODS: Normal and glaucomatous eyes enrolled from four clinical sites underwent complete examination, automated perimetry, SLP-ECC, and SLP-VCC. Eyes were characterized in three groups based upon the typical scan score (TSS): normal birefringence pattern (NBP) was defined as TSS > or = 80, mild ABP as TSS 61 to 79, and moderate-severe ABP as TSS < or = 60. For each of four SLP parameters, the area under the ROC curve (AUROC) was calculated to compare the ability of SLP-ECC and SLP-VCC to discriminate between normal and glaucomatous eyes. RESULTS: Eighty-four normal volunteers and 45 glaucomapatients were enrolled. Mean TSS was significantly (P < .001) greater using SLP-ECC (98.0 +/- 6.6) compared with SLP-VCC (83.4 +/- 22.5). The frequency of moderate-severe ABP images was significantly (P < .001, McNemar test) higher using SLP-VCC (18 of 129, 14%) compared with SLP-ECC (one of 129, 0.8%). Two SLP-ECC parameters (temporal superior nasal inferior temporal [TSNIT] average and inferior average) had significantly (P = .01, P < .001) higher correlation (r = .45, r = .50, respectively) with MD compared with SLP-VCC (r = .34, r = .37). Among eyes with moderate-severe ABP (n = 18), inferior average obtained using SLP-ECC had significantly (P = .03) greater AUROC (0.91 +/- 0.07) compared with SLP-VCC (0.78 +/- 0.11). CONCLUSIONS: SLP-ECC significantly reduces the frequency and severity of ABP compared with SLP-VCC and improves the correlation between RNFL measures and visual function.
Authors: Dana P Tannenbaum; Douglas Hoffman; Hans G Lemij; David F Garway-Heath; David S Greenfield; Joseph Caprioli Journal: Ophthalmology Date: 2004-02 Impact factor: 12.079
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Authors: Harsha L Rao; Ravi K Yadav; Uday K Addepalli; Shashikant Chaudhary; Sirisha Senthil; Nikhil S Choudhari; Chandra S Garudadri Journal: PLoS One Date: 2014-10-03 Impact factor: 3.240