BACKGROUND/AIMS: The use of intraoperative frozen section to determine the extent of margin resection is a common practice. Our aim was to identify the value of intraoperative frozen section in margin evaluation and to investigate its indication for gastric cancer of the cardia. METHODOLOGY: Intraoperative frozen section examinations of the proximal margins of 66 patients with gastric adenocarcinoma of the cardia were reviewed. The frozen section results were compared with those of the permanent sections. Clinicopathological features that predict a positive frozen section margin were examined by univariate and multivariate analysis. RESULTS: The overall accuracy, sensitivity and specificity of an intraoperative frozen section, was 97%, 77.8%, and 100%, respectively. Infiltration on frozen section occurred in 10.7% (7/66) of the proximal margins, while in 28.6% (2/7) of the entire additional resection margins. The positive margins were associated with more advanced in depth of tumor invasion and disease stage. However, the depth of invasion was the only independent predictor for a positive frozen margin. CONCLUSIONS: Routine evaluation of the proximal resection margin by intraoperative frozen section does not appear to be necessary in gastric cancer surgery of the cardia. However, this technique is advisable for patients with T3 or T4 lesions.
BACKGROUND/AIMS: The use of intraoperative frozen section to determine the extent of margin resection is a common practice. Our aim was to identify the value of intraoperative frozen section in margin evaluation and to investigate its indication for gastric cancer of the cardia. METHODOLOGY: Intraoperative frozen section examinations of the proximal margins of 66 patients with gastric adenocarcinoma of the cardia were reviewed. The frozen section results were compared with those of the permanent sections. Clinicopathological features that predict a positive frozen section margin were examined by univariate and multivariate analysis. RESULTS: The overall accuracy, sensitivity and specificity of an intraoperative frozen section, was 97%, 77.8%, and 100%, respectively. Infiltration on frozen section occurred in 10.7% (7/66) of the proximal margins, while in 28.6% (2/7) of the entire additional resection margins. The positive margins were associated with more advanced in depth of tumor invasion and disease stage. However, the depth of invasion was the only independent predictor for a positive frozen margin. CONCLUSIONS: Routine evaluation of the proximal resection margin by intraoperative frozen section does not appear to be necessary in gastric cancer surgery of the cardia. However, this technique is advisable for patients with T3 or T4 lesions.
Authors: Jordan Levy; Vaibhav Gupta; Elmira Amirazodi; Catherine Allen-Ayodabo; Naheed Jivraj; Yunni Jeong; Laura E Davis; Alyson L Mahar; Charles De Mestral; Olli Saarela; Natalie Coburn Journal: Gastric Cancer Date: 2019-11-04 Impact factor: 7.370
Authors: Livia S Eberlin; Robert J Tibshirani; Jialing Zhang; Teri A Longacre; Gerald J Berry; David B Bingham; Jeffrey A Norton; Richard N Zare; George A Poultsides Journal: Proc Natl Acad Sci U S A Date: 2014-02-03 Impact factor: 11.205
Authors: Massimiliano Bissolati; Matteo Desio; Fausto Rosa; Stefano Rausei; Daniele Marrelli; Gian Luca Baiocchi; Giovanni De Manzoni; Damiano Chiari; Giovanni Guarneri; Fabio Pacelli; Lorenzo De Franco; Sarah Molfino; Chiara Cipollari; Elena Orsenigo Journal: Gastric Cancer Date: 2016-01-05 Impact factor: 7.370
Authors: Livia S Eberlin; Katherine Margulis; Ivette Planell-Mendez; Richard N Zare; Robert Tibshirani; Teri A Longacre; Moe Jalali; Jeffrey A Norton; George A Poultsides Journal: PLoS Med Date: 2016-08-30 Impact factor: 11.069
Authors: Leonie R van der Werf; Charlotte Cords; Ivo Arntz; Eric J T Belt; Ivan M Cherepanin; Peter-Paul L O Coene; Erwin van der Harst; Joos Heisterkamp; Barbara S Langenhoff; Bas Lamme; Mark I van Berge Henegouwen; Sjoerd M Lagarde; Bas P L Wijnhoven Journal: Ann Surg Oncol Date: 2019-04-22 Impact factor: 5.344