| Literature DB >> 17145945 |
Claudia Gianfaldoni1, Stefano Censini, Markus Hilleringmann, Monica Moschioni, Claudia Facciotti, Werner Pansegrau, Vega Masignani, Antonello Covacci, Rino Rappuoli, Michèle Anne Barocchi, Paolo Ruggiero.
Abstract
Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype 4 strain TIGR4.Entities:
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Year: 2006 PMID: 17145945 PMCID: PMC1828493 DOI: 10.1128/IAI.01400-06
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441