| Literature DB >> 15994562 |
Domenico Maione1, Immaculada Margarit, Cira D Rinaudo, Vega Masignani, Marirosa Mora, Maria Scarselli, Hervé Tettelin, Cecilia Brettoni, Emilia T Iacobini, Roberto Rosini, Nunzio D'Agostino, Lisa Miorin, Scilla Buccato, Massimo Mariani, Giuliano Galli, Renzo Nogarotto, Vincenzo Nardi-Dei, Vincenzo Nardi Dei, Filipo Vegni, Claire Fraser, Giuseppe Mancuso, Giuseppe Teti, Lawrence C Madoff, Lawrence C Paoletti, Rino Rappuoli, Dennis L Kasper, John L Telford, Guido Grandi.
Abstract
Group B Streptococcus (GBS) is a multiserotype bacterial pathogen representing a major cause of life-threatening infections in newborns. To develop a broadly protective vaccine, we analyzed the genome sequences of eight GBS isolates and cloned and tested 312 surface proteins as vaccines. Four proteins elicited protection in mice, and their combination proved highly protective against a large panel of strains, including all circulating serotypes. Protection also correlated with antigen accessibility on the bacterial surface and with the induction of opsonophagocytic antibodies. Multigenome analysis and screening described here represent a powerful strategy for identifying potential vaccine candidates against highly variable pathogens.Entities:
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Year: 2005 PMID： 15994562 PMCID： PMC1351092 DOI： 10.1126/science.1109869
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728