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Literature DB >> 17142778

Biomechanical signals suppress proinflammatory responses in cartilage: early events in experimental antigen-induced arthritis.

Mario Ferretti¹, Robert Gassner, Zheng Wang, Priyangi Perera, James Deschner, Gwendolyn Sowa, Robert B Salter, Sudha Agarwal.

Abstract

Although biomechanical signals generated during joint mobilization are vital in maintaining integrity of inflamed cartilage, the molecular mechanisms of their actions are little understood. In an experimental model of arthritis, we demonstrate that biomechanical signals are potent anti-inflammatory signals that repress transcriptional activation of proinflammatory genes and augment expression of anti-inflammatory cytokine IL-10 to profoundly attenuate localized joint inflammation.

Entities: Disease Gene

Mesh：

Substances：
Antigens
Interleukin-10

Year: 2006 PMID： 17142778 PMCID： PMC4948981 DOI： 10.4049/jimmunol.177.12.8757

Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422

38 in total

1. Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis.

Authors: Jon D Szafranski; Alan J Grodzinsky; Elke Burger; Veronique Gaschen; Han-Hwa Hung; Ernst B Hunziker
Journal: Osteoarthritis Cartilage Date: 2004-12 Impact factor: 6.576

2. Efficacy of continuous passive motion following total knee arthroplasty: a metaanalysis.

Authors: Lucie Brosseau; Sarah Milne; George Wells; Peter Tugwell; Vivian Robinson; Lynn Casimiro; Lucie Pelland; Marie-Josée Noel; Jennifer Davis; Hugo Drouin
Journal: J Rheumatol Date: 2004-11 Impact factor: 4.666

Review 3. Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide.

Authors: Richard F Loeser
Journal: Arthritis Rheum Date: 2006-05

4. Roles for the interleukin-4 receptor and associated JAK/STAT proteins in human articular chondrocyte mechanotransduction.

Authors: S J Millward-Sadler; N S Khan; M G Bracher; M O Wright; D M Salter
Journal: Osteoarthritis Cartilage Date: 2006-05-06 Impact factor: 6.576

5. Viral IL-10 and soluble TNF receptor act synergistically to inhibit collagen-induced arthritis following adenovirus-mediated gene transfer.

Authors: K N Kim; S Watanabe; Y Ma; S Thornton; E H Giannini; R Hirsch
Journal: J Immunol Date: 2000-02-01 Impact factor: 5.422

6. Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis.

Authors: Ewa M Roos; Leif Dahlberg
Journal: Arthritis Rheum Date: 2005-11

7. Anti-inflammatory effects of continuous passive motion on meniscal fibrocartilage.

Authors: Mario Ferretti; Abiraman Srinivasan; James Deschner; Robert Gassner; Frank Baliko; Nicholas Piesco; Robert Salter; Sudha Agarwal
Journal: J Orthop Res Date: 2005-04-22 Impact factor: 3.494

8. Osteoarthritis cartilage histopathology: grading and staging.

Authors: K P H Pritzker; S Gay; S A Jimenez; K Ostergaard; J-P Pelletier; P A Revell; D Salter; W B van den Berg
Journal: Osteoarthritis Cartilage Date: 2005-10-19 Impact factor: 6.576

9. Interleukin-10 and interleukin-10 receptor in human osteoarthritic and healthy chondrocytes.

Authors: F Iannone; C De Bari; F Dell'Accio; M Covelli; F P Cantatore; V Patella; G Lo Bianco; G Lapadula
Journal: Clin Exp Rheumatol Date: 2001 Mar-Apr Impact factor: 4.473

Review 10. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators.

Authors: Jean-Christophe Renauld
Journal: Nat Rev Immunol Date: 2003-08 Impact factor: 53.106

23 in total

1. Changes of the Functional Capacity of Mesenchymal Stem Cells due to Aging or Age-Associated Disease - Implications for Clinical Applications and Donor Recruitment.

Authors: Günter Lepperdinger; Regina Brunauer; Robert Gassner; Angelika Jamnig; Frank Kloss; Gerhard Thomas Laschober
Journal: Transfus Med Hemother Date: 2008-07-17 Impact factor: 3.747

2. Biomechanical signals suppress TAK1 activation to inhibit NF-kappaB transcriptional activation in fibrochondrocytes.

Authors: Shashi Madhavan; Mirela Anghelina; Danen Sjostrom; Anar Dossumbekova; Denis C Guttridge; Sudha Agarwal
Journal: J Immunol Date: 2007-11-01 Impact factor: 5.422

3. Arthroscopic partial anterior synovectomy of the knee on patients with haemophilia.

Authors: Adriano Marques de Almeida; Marcia Uchoa de Rezende; Felippi Guizardi Cordeiro; Paula Ribeiro Villaça; Elbio Antonio D'Amico; Arnaldo José Hernandez; Gilberto Luis Camanho
Journal: Knee Surg Sports Traumatol Arthrosc Date: 2015-03 Impact factor: 4.342

Biomechanical signals suppress proinflammatory responses in cartilage: early events in experimental antigen-induced arthritis.

1. Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis.

2. Efficacy of continuous passive motion following total knee arthroplasty: a metaanalysis.

Review 3. Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide.

4. Roles for the interleukin-4 receptor and associated JAK/STAT proteins in human articular chondrocyte mechanotransduction.

5. Viral IL-10 and soluble TNF receptor act synergistically to inhibit collagen-induced arthritis following adenovirus-mediated gene transfer.

6. Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis.

7. Anti-inflammatory effects of continuous passive motion on meniscal fibrocartilage.

8. Osteoarthritis cartilage histopathology: grading and staging.

9. Interleukin-10 and interleukin-10 receptor in human osteoarthritic and healthy chondrocytes.

Review 10. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators.

1. Changes of the Functional Capacity of Mesenchymal Stem Cells due to Aging or Age-Associated Disease - Implications for Clinical Applications and Donor Recruitment.

2. Biomechanical signals suppress TAK1 activation to inhibit NF-kappaB transcriptional activation in fibrochondrocytes.

3. Arthroscopic partial anterior synovectomy of the knee on patients with haemophilia.

4. Exercise-driven metabolic pathways in healthy cartilage.

5. The regional sensitivity of chondrocyte gene expression to coactive mechanical load and exogenous TNF-α stimuli.

Review 6. Biological basis of exercise-based treatments for musculoskeletal conditions.

7. High resolution micro arthrography of hard and soft tissues in a murine model.

8. Development and validation of a motion and loading system for a rat knee joint in vivo.

9. Mechanical loading: potential preventive and therapeutic strategy for osteoarthritis.

10. Changes in surface topologies of chondrocytes subjected to mechanical forces: an AFM analysis.