BACKGROUND: A functional polymorphism in the promoter region of the monoamine oxidase A (MAO A) gene has two common alleles that are referred to as the high and low MAO A genotypes. We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects. METHODS: Brain MAO A activity was measured with positron emission tomography and [(11)C]clorgyline in 38 healthy adult male nonsmokers genotyped for MAO A polymorphism. RESULTS: There was no significant difference in brain MAO A activity between the high (n = 26) and low (n = 12) MAO A genotypes. CONCLUSIONS: The lack of an association between the high and low MAO A genotype and brain MAO A activity suggests that this polymorphism by itself does not contribute to differences in brain MAO A activity in healthy adult male subjects.
BACKGROUND: A functional polymorphism in the promoter region of the monoamine oxidase A (MAO A) gene has two common alleles that are referred to as the high and low MAO A genotypes. We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects. METHODS: Brain MAO A activity was measured with positron emission tomography and [(11)C]clorgyline in 38 healthy adult male nonsmokers genotyped for MAO A polymorphism. RESULTS: There was no significant difference in brain MAO A activity between the high (n = 26) and low (n = 12) MAO A genotypes. CONCLUSIONS: The lack of an association between the high and low MAO A genotype and brain MAO A activity suggests that this polymorphism by itself does not contribute to differences in brain MAO A activity in healthy adult male subjects.
Authors: J S Fowler; J Logan; Y S Ding; D Franceschi; G J Wang; N D Volkow; N Pappas; D Schlyer; S J Gatley; D Alexoff; C Felder; A Biegon; W Zhu Journal: J Neurochem Date: 2001-12 Impact factor: 5.372
Authors: Avshalom Caspi; Joseph McClay; Terrie E Moffitt; Jonathan Mill; Judy Martin; Ian W Craig; Alan Taylor; Richie Poulton Journal: Science Date: 2002-08-02 Impact factor: 47.728
Authors: Brian J Mickey; Francesca Ducci; Colin A Hodgkinson; Scott A Langenecker; David Goldman; Jon-Kar Zubieta Journal: J Neurosci Date: 2008-10-29 Impact factor: 6.167