Literature DB >> 18566880

Association of a monoamine oxidase-a gene promoter polymorphism with ADHD and anxiety in boys with autism spectrum disorder.

Jasmin Roohi1, Carla J DeVincent, Eli Hatchwell, Kenneth D Gadow.   

Abstract

The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism in the promoter region of the MAO-A gene and severity of ADHD and anxiety in boys with ASD. Parents and teachers completed a DSM-IV-referenced rating scale for 5- to 14-year-old boys with ASD (n = 43). Planned comparisons indicated that children with the 4- versus 3-repeat allele had significantly (p < 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety. Our results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding.

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Year:  2008        PMID： 18566880      PMCID： PMC4358843          DOI： 10.1007/s10803-008-0600-8

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  44 in total

1.  Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder.

Authors:  J Deckert; M Catalano; Y V Syagailo; M Bosi; O Okladnova; D Di Bella; M M Nöthen; P Maffei; P Franke; J Fritze; W Maier; P Propping; H Beckmann; L Bellodi; K P Lesch
Journal:  Hum Mol Genet       Date:  1999-04       Impact factor: 6.150

2.  Parent-rated anxiety symptoms in children with pervasive developmental disorders: frequency and association with core autism symptoms and cognitive functioning.

Authors:  Denis G Sukhodolsky; Lawrence Scahill; Kenneth D Gadow; L Eugene Arnold; Michael G Aman; Christopher J McDougle; James T McCracken; Elaine Tierney; Susan Williams White; Luc Lecavalier; Benedetto Vitiello
Journal:  J Abnorm Child Psychol       Date:  2007-08-03

3.  The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism.

Authors:  C Lord; S Risi; L Lambrecht; E H Cook; B L Leventhal; P C DiLavore; A Pickles; M Rutter
Journal:  J Autism Dev Disord       Date:  2000-06

4.  Family-based and population study of a functional promoter-region monoamine oxidase A polymorphism in autism: possible association with IQ.

Authors:  Nurit Yirmiya; Tammy Pilowsky; Sigal Tidhar; Lubov Nemanov; Larissa Altmark; Richard P Ebstein
Journal:  Am J Med Genet       Date:  2002-04-08

5.  Behaviour and emotional problems in toddlers with pervasive developmental disorders and developmental delay: associations with parental mental health and family functioning.

Authors:  S Herring; K Gray; J Taffe; B Tonge; D Sweeney; S Einfeld
Journal:  J Intellect Disabil Res       Date:  2006-12

6.  Medication patterns in patients with autism: temporal, regional, and demographic influences.

Authors:  Michael G Aman; Kristen S L Lam; Mary E Van Bourgondien
Journal:  J Child Adolesc Psychopharmacol       Date:  2005-02       Impact factor: 2.576

7.  Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum.

Authors:  Jerzy Samochowiec; Anna Hajduk; Agnieszka Samochowiec; Jan Horodnicki; Genowefa Stepień; Anna Grzywacz; Jolanta Kucharska-Mazur
Journal:  Psychiatry Res       Date:  2004-08-30       Impact factor: 3.222

8.  Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder.

Authors:  Deborah C Lawson; Darko Turic; Kate Langley; Helen M Pay; Catherine F Govan; Nadine Norton; Marian L Hamshere; Michael J Owen; Michael C O'Donovan; Anita Thapar
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2003-01-01       Impact factor: 3.568

9.  MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis.

Authors:  J Kim-Cohen; A Caspi; A Taylor; B Williams; R Newcombe; I W Craig; T E Moffitt
Journal:  Mol Psychiatry       Date:  2006-06-27       Impact factor: 15.992

10.  Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity.

Authors:  Luca Passamonti; Francesco Fera; Angela Magariello; Antonio Cerasa; Maria Cecilia Gioia; Maria Muglia; Giuseppe Nicoletti; Olivier Gallo; Leandro Provinciali; Aldo Quattrone
Journal:  Biol Psychiatry       Date:  2005-10-03       Impact factor: 13.382
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  19 in total

1.  Comparison of children with autism spectrum disorder with and without schizophrenia spectrum traits: gender, season of birth, and mental health risk factors.

Authors:  Kenneth D Gadow; Carla J DeVincent
Journal:  J Autism Dev Disord       Date:  2012-11

2.  Association of positive and negative parenting behavior with childhood ADHD: interactions with offspring monoamine oxidase A (MAO-A) genotype.

Authors:  James J Li; Steve S Lee
Journal:  J Abnorm Child Psychol       Date:  2012-02

3.  Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder.

Authors:  Kenneth D Gadow; Julia K Pinsonneault; Greg Perlman; Wolfgang Sadee
Journal:  Res Dev Disabil       Date:  2014-04-26

4.  MAOA, DBH, and SLC6A4 variants in CHARGE: a case-control study of autism spectrum disorders.

Authors:  Flora Tassone; Lihong Qi; Wenting Zhang; Robin L Hansen; Isaac N Pessah; Irva Hertz-Picciotto
Journal:  Autism Res       Date:  2011-04-29       Impact factor: 5.216

5.  The Treatment of Anxiety in Autism Spectrum Disorder (TAASD) Study: Rationale, Design and Methods.

Authors:  Connor M Kerns; Jeffrey J Wood; Philip C Kendall; Patricia Renno; Erika A Crawford; Rogelio J Mercado; Cori Fujii; Amanda Collier; Alexandra Hoff; Elana R Kagan; Brent J Small; Adam B Lewin; Eric A Storch
Journal:  J Child Fam Stud       Date:  2016-02-06

Review 6.  Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder.

Authors:  Nanda N J Rommelse; Barbara Franke; Hilde M Geurts; Catharina A Hartman; Jan K Buitelaar
Journal:  Eur Child Adolesc Psychiatry       Date:  2010-02-11       Impact factor: 4.785

7.  Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans.

Authors:  Andrea M Dlugos; Abraham A Palmer; Harriet de Wit
Journal:  J Neural Transm (Vienna)       Date:  2009-08-06       Impact factor: 3.575

8.  Allele-specific associations of 5-HTTLPR/rs25531 with ADHD and autism spectrum disorder.

Authors:  Kenneth D Gadow; Carla J DeVincent; Victoria I Siegal; Doreen M Olvet; Saniya Kibria; Sarah F Kirsch; Eli Hatchwell
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2012-10-31       Impact factor: 5.067

9.  Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder.

Authors:  Kenneth D Gadow; Jasmin Roohi; Carla J DeVincent; Eli Hatchwell
Journal:  J Child Psychol Psychiatry       Date:  2008-12       Impact factor: 8.982

10.  Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder.

Authors:  Kenneth D Gadow; Jasmin Roohi; Carla J DeVincent; Sarah Kirsch; Eli Hatchwell
Journal:  J Autism Dev Disord       Date:  2009-07-07
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