| Literature DB >> 1712482 |
C L Walker1, C B Cargile, K M Floy, M Delannoy, B R Migeon.
Abstract
We examined Barr bodies formed by isodicentric human X chromosomes in cultured human cells and in mouse-human hybrids using confocal microscopy and DNA probes for centromere and subtelomere regions. At interphase, the two ends of these chromosomes are only a micron apart, indicating that these inactive X chromosomes are in a nonlinear configuration. Additional studies of normal X chromosomes reveal the same telomere association for the inactive X but not for the active X chromosome. This nonlinear configuration is maintained during mitosis and in a murine environment.Entities:
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Year: 1991 PMID: 1712482 PMCID: PMC52048 DOI: 10.1073/pnas.88.14.6191
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205