Literature DB >> 17110213

Systems cell biology based on high-content screening.

Kenneth A Giuliano1, Patricia A Johnston, Albert Gough, D Lansing Taylor.   

Abstract

A new discipline of biology has emerged since 2004, which we call "systems cell biology" (SCB). Systems cell biology is the study of the living cell, the basic unit of life, an integrated and interacting network of genes, proteins, and myriad metabolic reactions that give rise to function. SCB takes advantage of high-content screening platforms, but delivers more detailed profiles of cellular systemic function, including the application of advanced reagents and informatics tools to sophisticated cellular models. Therefore, an SCB profile is a cellular systemic response as measured by a panel of reagents that quantify a specific set of biomarkers.

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Year:  2006        PMID： 17110213     DOI： 10.1016/S0076-6879(06)14031-8

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


  17 in total

Review 1.  Thinking inside the box. To cope with an increasing disease burden, drug discovery needs biologically relevant and predictive testing systems.

Authors:  Lars E Sundstrom
Journal:  EMBO Rep       Date:  2007-07       Impact factor: 8.807

2.  Quantification of lipid droplets and associated proteins in cellular models of obesity via high-content/high-throughput microscopy and automated image analysis.

Authors:  Patrick M McDonough; Ramses M Agustin; Randall S Ingermanson; Patricia A Loy; Benjamin M Buehrer; James B Nicoll; Natalie L Prigozhina; Ivana Mikic; Jeffrey H Price
Journal:  Assay Drug Dev Technol       Date:  2009-10       Impact factor: 1.738

3.  Using Caenorhabditis elegans to study serpinopathies.

Authors:  Olivia S Long; Sager J Gosai; Joon Hyeok Kwak; Dale E King; David H Perlmutter; Gary A Silverman; Stephen C Pak
Journal:  Methods Enzymol       Date:  2011       Impact factor: 1.600

Review 4.  Screening the cellular microenvironment: a role for microfluidics.

Authors:  Jay W Warrick; William L Murphy; David J Beebe
Journal:  IEEE Rev Biomed Eng       Date:  2008-11-05

5.  Structure, affinity, and availability of estrogen receptor complexes in the cellular environment.

Authors:  Eric M Kofoed; Martin Guerbadot; Fred Schaufele
Journal:  J Biol Chem       Date:  2009-11-19       Impact factor: 5.157

6.  Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Authors:  Richard Judson; Keith Houck; Matt Martin; Ann M Richard; Thomas B Knudsen; Imran Shah; Stephen Little; John Wambaugh; R Woodrow Setzer; Parth Kothiya; Jimmy Phuong; Dayne Filer; Doris Smith; David Reif; Daniel Rotroff; Nicole Kleinstreuer; Nisha Sipes; Menghang Xia; Ruili Huang; Kevin Crofton; Russell S Thomas
Journal:  Toxicol Sci       Date:  2016-05-20       Impact factor: 4.849

7.  Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z.

Authors:  Sager J Gosai; Joon Hyeok Kwak; Cliff J Luke; Olivia S Long; Dale E King; Kevin J Kovatch; Paul A Johnston; Tong Ying Shun; John S Lazo; David H Perlmutter; Gary A Silverman; Stephen C Pak
Journal:  PLoS One       Date:  2010-11-12       Impact factor: 3.240

8.  Endocrine profiling and prioritization of environmental chemicals using ToxCast data.

Authors:  David M Reif; Matthew T Martin; Shirlee W Tan; Keith A Houck; Richard S Judson; Ann M Richard; Thomas B Knudsen; David J Dix; Robert J Kavlock
Journal:  Environ Health Perspect       Date:  2010-09-08       Impact factor: 9.031

9.  Translocation Biosensors - Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics.

Authors:  Verena Fetz; Shirley K Knauer; Carolin Bier; Jens Peter von Kries; Roland H Stauber
Journal:  Sensors (Basel)       Date:  2009-07-09       Impact factor: 3.576

10.  Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays.

Authors:  Nisha S Sipes; Matthew T Martin; Parth Kothiya; David M Reif; Richard S Judson; Ann M Richard; Keith A Houck; David J Dix; Robert J Kavlock; Thomas B Knudsen
Journal:  Chem Res Toxicol       Date:  2013-05-16       Impact factor: 3.739
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