BACKGROUND AND PURPOSE: The present study assessed beta-amyloid (Abeta) protein aggregates in postmortem human brains in subjects who had experienced stroke to examine the proposed association between ischemic stress and the accumulation of Abeta reported in rodents. METHODS: A sample of 484 postmortem brains from nondemented subjects, lacking isocortical neurodegenerative pathology with verified cerebrovascular lesions, and 57 age-matched controls were assessed with respect to Abeta, Abeta40, and Abeta42 aggregates in the cortex and thalamus by immunohistochemical techniques. RESULTS: The load of Abeta aggregates did not display a significant association with cerebrovascular lesions. The load of Abeta, Abeta40, and Abeta42 aggregates increased with age, and there was a tendency toward higher odds ratios for Abeta aggregates, though not statistically significant, in subjects with acute cerebrovascular lesions. In the oldest subjects with cerebrovascular lesions and with both thalamic and cortical Abeta aggregates, the load of thalamic Abeta42 was significantly higher than the load of Abeta40. CONCLUSIONS: Our findings indicate that cerebrovascular disease does not influence the load of Abeta, whereas a shift of aggregation from the Abeta40 to the Abeta42 residue is noted in the thalamus but only in aged subjects. It is impossible, however, to state whether this result is attributable to increased Abeta production, its insufficient elimination, or other susceptibility factors.
BACKGROUND AND PURPOSE: The present study assessed beta-amyloid (Abeta) protein aggregates in postmortem human brains in subjects who had experienced stroke to examine the proposed association between ischemic stress and the accumulation of Abeta reported in rodents. METHODS: A sample of 484 postmortem brains from nondemented subjects, lacking isocortical neurodegenerative pathology with verified cerebrovascular lesions, and 57 age-matched controls were assessed with respect to Abeta, Abeta40, and Abeta42 aggregates in the cortex and thalamus by immunohistochemical techniques. RESULTS: The load of Abeta aggregates did not display a significant association with cerebrovascular lesions. The load of Abeta, Abeta40, and Abeta42 aggregates increased with age, and there was a tendency toward higher odds ratios for Abeta aggregates, though not statistically significant, in subjects with acute cerebrovascular lesions. In the oldest subjects with cerebrovascular lesions and with both thalamic and cortical Abeta aggregates, the load of thalamic Abeta42 was significantly higher than the load of Abeta40. CONCLUSIONS: Our findings indicate that cerebrovascular disease does not influence the load of Abeta, whereas a shift of aggregation from the Abeta40 to the Abeta42 residue is noted in the thalamus but only in aged subjects. It is impossible, however, to state whether this result is attributable to increased Abeta production, its insufficient elimination, or other susceptibility factors.
Authors: Yong Soo Shim; Dong-Won Yang; Catherine M Roe; Mary A Coats; Tammie L Benzinger; Chengjie Xiong; James E Galvin; Nigel J Cairns; John C Morris Journal: Dement Geriatr Cogn Disord Date: 2014-11-08 Impact factor: 2.959
Authors: Lilia Y Kucheryavykh; Josué Dávila-Rodríguez; David E Rivera-Aponte; Lidia V Zueva; A Valance Washington; Priscilla Sanabria; Mikhail Y Inyushin Journal: Brain Res Bull Date: 2016-11-28 Impact factor: 4.077
Authors: Irina Alafuzoff; Dietmar R Thal; Thomas Arzberger; Nenad Bogdanovic; Safa Al-Sarraj; Istvan Bodi; Susan Boluda; Orso Bugiani; Charles Duyckaerts; Ellen Gelpi; Stephen Gentleman; Giorgio Giaccone; Manuel Graeber; Tibor Hortobagyi; Romana Höftberger; Paul Ince; James W Ironside; Nikolaos Kavantzas; Andrew King; Penelope Korkolopoulou; Gábor G Kovács; David Meyronet; Camelia Monoranu; Tatjana Nilsson; Piero Parchi; Efstratios Patsouris; Maria Pikkarainen; Tamas Revesz; Annemieke Rozemuller; Danielle Seilhean; Walter Schulz-Schaeffer; Nathalie Streichenberger; Stephen B Wharton; Hans Kretzschmar Journal: Acta Neuropathol Date: 2009-02-01 Impact factor: 17.088