BACKGROUND/AIMS: We investigated the histopathological correlates of white matter hyperintensities (WMHs) in participants with Alzheimer's disease (AD) or cerebrovascular disease, and in aged controls. METHODS: We reviewed 57 participants who had neuropathology and in whom neuroimaging was done. In addition to AD pathology, cortical microinfarcts, lacunes, and cerebral hemorrhages were assessed. Small-vessel disease included arteriolosclerosis and cerebral amyloid angiopathy. Postmortem brain tissue corresponding to regions of WMHs was investigated in 14 participants. The variables included: demyelination of the deep and periventricular white matter (WM), atrophy of the ventricular ependyma, and thickness of blood vessels. Partial Spearman's rank test and linear regression analysis, adjusted for age at the clinical evaluation and the duration to death, were performed. RESULTS: The severity of arteriosclerosis was correlated with the volume of periventricular hyperintensity (PVH) estimated by magnetic resonance imaging. Deep white matter hyperintensity (DWMH) volume was correlated with the presence of cortical microinfarcts and cerebral hemorrhages. The severity of the breakdown of the ventricular lining was correlated with PVHs, and DWMHs correlated with the severity of deep WM demyelination. The diameter of small blood vessels was not associated with WMHs. CONCLUSION: WMHs are consistent with small-vessel disease and increase the tissue water content. We found no association between WMHs and the thickness of small blood vessels.
BACKGROUND/AIMS: We investigated the histopathological correlates of white matter hyperintensities (WMHs) in participants with Alzheimer's disease (AD) or cerebrovascular disease, and in aged controls. METHODS: We reviewed 57 participants who had neuropathology and in whom neuroimaging was done. In addition to AD pathology, cortical microinfarcts, lacunes, and cerebral hemorrhages were assessed. Small-vessel disease included arteriolosclerosis and cerebral amyloid angiopathy. Postmortem brain tissue corresponding to regions of WMHs was investigated in 14 participants. The variables included: demyelination of the deep and periventricular white matter (WM), atrophy of the ventricular ependyma, and thickness of blood vessels. Partial Spearman's rank test and linear regression analysis, adjusted for age at the clinical evaluation and the duration to death, were performed. RESULTS: The severity of arteriosclerosis was correlated with the volume of periventricular hyperintensity (PVH) estimated by magnetic resonance imaging. Deep white matter hyperintensity (DWMH) volume was correlated with the presence of cortical microinfarcts and cerebral hemorrhages. The severity of the breakdown of the ventricular lining was correlated with PVHs, and DWMHs correlated with the severity of deep WM demyelination. The diameter of small blood vessels was not associated with WMHs. CONCLUSION: WMHs are consistent with small-vessel disease and increase the tissue water content. We found no association between WMHs and the thickness of small blood vessels.
Authors: Malee S Fernando; Julie E Simpson; Fiona Matthews; Carol Brayne; Claire E Lewis; Robert Barber; Raj N Kalaria; Gill Forster; Filomena Esteves; Stephen B Wharton; Pamela J Shaw; John T O'Brien; Paul G Ince Journal: Stroke Date: 2006-04-20 Impact factor: 7.914
Authors: Jeffrey M Burns; Jessica A Church; David K Johnson; Chengjie Xiong; Daniel Marcus; Anthony F Fotenos; Abraham Z Snyder; John C Morris; Randy L Buckner Journal: Arch Neurol Date: 2005-12
Authors: Duane L Beekly; Erin M Ramos; Gerald van Belle; Woodrow Deitrich; Amber D Clark; Mary E Jacka; Walter A Kukull Journal: Alzheimer Dis Assoc Disord Date: 2004 Oct-Dec Impact factor: 2.703
Authors: E Auriel; N M Bornstein; E Berenyi; I Varkonyi; M Gabor; K Majtenyi; R Szepesi; I Goldberg; R Lampe; L Csiba Journal: Acta Neurol Scand Date: 2011-01 Impact factor: 3.209
Authors: Wiesje M van der Flier; Elizabeth C W van Straaten; Frederik Barkhof; Ana Verdelho; Sofia Madureira; Leonardo Pantoni; Domenico Inzitari; Timo Erkinjuntti; Militta Crisby; Gunhild Waldemar; Reinhold Schmidt; Franz Fazekas; Philip Scheltens Journal: Stroke Date: 2005-09-01 Impact factor: 7.914
Authors: Alison D Murray; Roger T Staff; Susan D Shenkin; Ian J Deary; John M Starr; Lawrence J Whalley Journal: Radiology Date: 2005-08-26 Impact factor: 11.105
Authors: Alida A Gouw; Alexandra Seewann; Wiesje M van der Flier; Frederik Barkhof; Annemieke M Rozemuller; Philip Scheltens; Jeroen J G Geurts Journal: J Neurol Neurosurg Psychiatry Date: 2010-10-09 Impact factor: 10.154
Authors: Reinhold Schmidt; Stefan Ropele; Christian Enzinger; Katja Petrovic; Stephen Smith; Helena Schmidt; Paul M Matthews; Franz Fazekas Journal: Ann Neurol Date: 2005-10 Impact factor: 10.422
Authors: Adam de Havenon; Chelsea Meyer; J Scott McNally; Matthew Alexander; Lee Chung Journal: Curr Atheroscler Rep Date: 2019-07-27 Impact factor: 5.113
Authors: Michael L Alosco; Michael A Sugarman; Lilah M Besser; Yorghos Tripodis; Brett Martin; Joseph N Palmisano; Neil W Kowall; Rhoda Au; Jesse Mez; Charles DeCarli; Thor D Stein; Ann C McKee; Ronald J Killiany; Robert A Stern Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Konstantinos Arfanakis; Arnold M Evia; Sue E Leurgans; Luis F C Cardoso; Arman Kulkarni; Nabil Alqam; Lucas F Lopes; Diego Vieira; David A Bennett; Julie A Schneider Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472
Authors: Seonjoo Lee; Fawad Viqar; Molly E Zimmerman; Atul Narkhede; Giuseppe Tosto; Tammie L S Benzinger; Daniel S Marcus; Anne M Fagan; Alison Goate; Nick C Fox; Nigel J Cairns; David M Holtzman; Virginia Buckles; Bernardino Ghetti; Eric McDade; Ralph N Martins; Andrew J Saykin; Colin L Masters; John M Ringman; Natalie S Ryan; Stefan Förster; Christoph Laske; Peter R Schofield; Reisa A Sperling; Stephen Salloway; Stephen Correia; Clifford Jack; Michael Weiner; Randall J Bateman; John C Morris; Richard Mayeux; Adam M Brickman Journal: Ann Neurol Date: 2016-04-27 Impact factor: 10.422
Authors: Dana R Jorgensen; C Elizabeth Shaaban; Clayton A Wiley; Peter J Gianaros; Joseph Mettenburg; Caterina Rosano Journal: Am J Physiol Heart Circ Physiol Date: 2018-02-02 Impact factor: 4.733
Authors: Swati Rane; Julia Owen; Daniel S Hippe; Brenna Cholerton; Cyrus P Zabetian; Tom Montine; Thomas J Grabowski Journal: J Neuroimaging Date: 2020-09-16 Impact factor: 2.486
Authors: Eseosa T Ighodaro; Erin L Abner; David W Fardo; Ai-Ling Lin; Yuriko Katsumata; Frederick A Schmitt; Richard J Kryscio; Gregory A Jicha; Janna H Neltner; Sarah E Monsell; Walter A Kukull; Debra K Moser; Frank Appiah; Adam D Bachstetter; Linda J Van Eldik; Peter T Nelson Journal: J Cereb Blood Flow Metab Date: 2016-01-06 Impact factor: 6.200