Literature DB >> 11804188

ABC proteins of Leishmania.

D Légaré1, S Cayer, A K Singh, D Richard, B Papadopoulou, M Ouellette.   

Abstract

ABC proteins were first characterized in the protozoan parasite Leishmania while studying mechanisms of drug resistance. PGPA is involved in resistance to arsenite and antimonite and it most likely confers resistance by sequestering metal-thiol conjugates into an intracellular vesicle. PGPA is part of gene family with at least four more members which are in search of a function. Leishmania also contains a P-glycoprotein, homologous to the mammalian MDR1, that is involved in multidrug resistance. The ongoing genome project of Leishmania has pinpointed several novel ABC transporters and experiments are carried out to study the function of the ABC proteins in drug resistance and in host-pathogen interactions.

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Year:  2001        PMID： 11804188     DOI： 10.1023/a:1012870904097

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  53 in total

1.  Amplification of ABC transporter gene pgpA and of other heavy metal resistance genes in Leishmania tarentolae and their study by gene transfection and gene disruption.

Authors:  M Ouellette; A Haimeur; K Grondin; D Légaré; B Papadopoulou
Journal:  Methods Enzymol       Date:  1998       Impact factor: 1.600

2.  The complete genome sequence of Escherichia coli K-12.

Authors:  F R Blattner; G Plunkett; C A Bloch; N T Perna; V Burland; M Riley; J Collado-Vides; J D Glasner; C K Rode; G F Mayhew; J Gregor; N W Davis; H A Kirkpatrick; M A Goeden; D J Rose; B Mau; Y Shao
Journal:  Science       Date:  1997-09-05       Impact factor: 47.728

3.  Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani.

Authors:  R Lira; S Sundar; A Makharia; R Kenney; A Gam; E Saraiva; D Sacks
Journal:  J Infect Dis       Date:  1999-08       Impact factor: 5.226

4.  Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania.

Authors:  A Haimeur; C Guimond; S Pilote; R Mukhopadhyay; B P Rosen; R Poulin; M Ouellette
Journal:  Mol Microbiol       Date:  1999-11       Impact factor: 3.501

5.  ABC transporters in Leishmania and their role in drug resistance.

Authors:  M Ouellette; D Légaré; A Haimeur; K Grondin; G Roy; C Brochu; B Papadopoulou
Journal:  Drug Resist Updat       Date:  1998-03       Impact factor: 18.500

Review 6.  Leishmaniasis.

Authors:  B L Herwaldt
Journal:  Lancet       Date:  1999-10-02       Impact factor: 79.321

7.  Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania.

Authors:  R Mukhopadhyay; S Dey; N Xu; D Gage; J Lightbody; M Ouellette; B P Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

8.  The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump.

Authors:  Z S Li; M Szczypka; Y P Lu; D J Thiele; P A Rea
Journal:  J Biol Chem       Date:  1996-03-15       Impact factor: 5.157

9.  Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.

Authors:  W Saurin; M Hofnung; E Dassa
Journal:  J Mol Evol       Date:  1999-01       Impact factor: 2.395

10.  Contribution of the Leishmania P-glycoprotein-related gene ltpgpA to oxyanion resistance.

Authors:  B Papadopoulou; G Roy; S Dey; B P Rosen; M Ouellette
Journal:  J Biol Chem       Date:  1994-04-22       Impact factor: 5.157
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  15 in total

Review 1.  Xenobiotic efflux in bacteria and fungi: a genomics update.

Authors:  Ravi D Barabote; Jose Thekkiniath; Richard E Strauss; Govindsamy Vediyappan; Joe A Fralick; Michael J San Francisco
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  2011

2.  J-binding protein 1 and J-binding protein 2 expression in clinical Leishmania major no response-antimonial isolates.

Authors:  Salman Ahmadian; Gilda Eslami; Ali Fatahi; Saeede Sadat Hosseini; Mahmoud Vakili; Vahid Ajamein Fahadan; Mourad Elloumi
Journal:  J Parasit Dis       Date:  2018-11-20

3.  Glibenclamide, a blocker of K+(ATP) channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis.

Authors:  Xenón Serrano-Martín; Gilberto Payares; Alexis Mendoza-León
Journal:  Antimicrob Agents Chemother       Date:  2006-10-02       Impact factor: 5.191

4.  Tissue expression pattern of ABCG transporter indicates functional roles in reproduction of Toxocara canis.

Authors:  Yong-Li Luo; Guang-Xu Ma; Yong-Fang Luo; Ce-Yan Kuang; Ai-Yun Jiang; Guo-Qing Li; Rong-Qiong Zhou
Journal:  Parasitol Res       Date:  2018-02-08       Impact factor: 2.289

5.  Comparative transcript expression analysis of miltefosine-sensitive and miltefosine-resistant Leishmania donovani.

Authors:  Arpita Kulshrestha; Vanila Sharma; Ruchi Singh; Poonam Salotra
Journal:  Parasitol Res       Date:  2014-01-22       Impact factor: 2.289

6.  Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania.

Authors:  José M Pérez-Victoria; Boris I Bavchvarov; Iván R Torrecillas; Marta Martínez-García; Carmen López-Martín; Mercedes Campillo; Santiago Castanys; Francisco Gamarro
Journal:  Antimicrob Agents Chemother       Date:  2011-06-06       Impact factor: 5.191

7.  The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesis.

Authors:  K C Carter; S Sundar; C Spickett; O C Pereira; A B Mullen
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

8.  Variability in sensitivity to arsenite does not correlate with arsenic accumulation rate in normal human lymphoblasts.

Authors:  Ping Li; Ahmed N Uddin; Zijuan Liu; Rita Mukhopadhyay; Elena V Komissarova; Barry P Rosen; Toby G Rossman
Journal:  Mol Cell Biochem       Date:  2004-01       Impact factor: 3.396

9.  Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays.

Authors:  Chantal Guimond; Nathalie Trudel; Christian Brochu; Nathalie Marquis; Amal El Fadili; Régis Peytavi; Guylaine Briand; Dave Richard; Nadine Messier; Barbara Papadopoulou; Jacques Corbeil; Michel G Bergeron; Danielle Légaré; Marc Ouellette
Journal:  Nucleic Acids Res       Date:  2003-10-15       Impact factor: 16.971

10.  Antimony resistance during Visceral Leishmaniasis: A possible consequence of serial mutations in ABC transporters of Leishmania species.

Authors:  Sukrat Sinha; Shanthy Sundaram; Vijay Kumar; Ashutosh Tripathi
Journal:  Bioinformation       Date:  2011-04-22
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