Literature DB >> 17086180

Targeted chromosome elimination from ES-somatic hybrid cells.

Hiroyuki Matsumura1, Masako Tada, Tomomi Otsuji, Kentaro Yasuchika, Norio Nakatsuji, Azim Surani, Takashi Tada.   

Abstract

To engineer a stem cell genome, we developed a technology for targeted elimination of chromosomes from mouse embryonic stem (ES)-somatic hybrid cells. Here we demonstrate the use of a universal chromosome elimination cassette (CEC) for elimination of a single embryonic stem cell (ESC)-derived chromosome 11 or 12, and also both copies of chromosome 6, which harbor pluripotency-associated genes including Nanog. We attribute hybrid-cell pluripotency to the expression of Nanog from the reprogrammed somatic-cell nuclei.

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Year:  2006        PMID： 17086180     DOI： 10.1038/nmeth973

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  30 in total

1.  A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.

Authors:  Kyoji Horie; Chikara Kokubu; Junko Yoshida; Keiko Akagi; Ayako Isotani; Akiko Oshitani; Kosuke Yusa; Ryuji Ikeda; Yue Huang; Allan Bradley; Junji Takeda
Journal:  Nat Methods       Date:  2011-10-23       Impact factor: 28.547

Review 2.  Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming.

Authors:  Rudolf Jaenisch; Richard Young
Journal:  Cell       Date:  2008-02-22       Impact factor: 41.582

3.  Efficiencies and mechanisms of nuclear reprogramming.

Authors:  V Pasque; K Miyamoto; J B Gurdon
Journal:  Cold Spring Harb Symp Quant Biol       Date:  2010-11-03

Review 4.  Promising new sources for pluripotent stem cells.

Authors:  Christian Leeb; Marcin Jurga; Colin McGuckin; Richard Moriggl; Lukas Kenner
Journal:  Stem Cell Rev Rep       Date:  2010-03       Impact factor: 5.739

5.  Recombination between inverted loxP sites is cytotoxic for proliferating cells and provides a simple tool for conditional cell ablation.

Authors:  Damien Grégoire; Marie Kmita
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-11       Impact factor: 11.205

Review 6.  Cell fusion for reprogramming pluripotency: toward elimination of the pluripotent genome.

Authors:  Danièle Pralong; Alan O Trounson; Paul J Verma
Journal:  Stem Cell Rev       Date:  2006       Impact factor: 5.739

7.  Induced pluripotent stem cell technology and stem cell therapy for diabetes.

Authors:  Robert J Drummond; Tilo Kunath; P Joseph Mee; James A Ross
Journal:  Exp Ther Med       Date:  2010-12-02       Impact factor: 2.447

Review 8.  Somatic cell dedifferentiation/reprogramming for regenerative medicine.

Authors:  Thiyagarajan Ramesh; Sun-Hee Lee; Choon-Soo Lee; Yoo-Wook Kwon; Hyun-Jai Cho
Journal:  Int J Stem Cells       Date:  2009-05       Impact factor: 2.500

9.  A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.

Authors:  Kevin B Jones; Virginia Piombo; Charles Searby; Gail Kurriger; Baoli Yang; Florian Grabellus; Peter J Roughley; Jose A Morcuende; Joseph A Buckwalter; Mario R Capecchi; Andrea Vortkamp; Val C Sheffield
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-22       Impact factor: 11.205

Review 10.  Patient-specific pluripotent stem cells: promises and challenges.

Authors:  Rouven Müller; Claudia Lengerke
Journal:  Nat Rev Endocrinol       Date:  2009-04       Impact factor: 43.330
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