Literature DB >> 17084081

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity.

Gerhard Puerstinger1, Jan Paeshuyse, Erik De Clercq, Johan Neyts.   

Abstract

A novel class of inhibitors of the hepatitis C virus [substituted 2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridines] is described. Introduction of a fluorine in position 2 of the 2-phenyl substituent of the lead anti-pestivirus compound 1 (5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine) resulted in an analogue with selective activity against HCV in the subgenomic replicon system.

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Year:  2006        PMID： 17084081     DOI： 10.1016/j.bmcl.2006.10.039

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions.

Authors:  Zhang-Gao Le; Zong-Bo Xie; Jian-Ping Xu
Journal:  Molecules       Date:  2012-11-09       Impact factor: 4.411

Review 2.  Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses.

Authors:  Rahul Kumar; Sahil Mishra; Sushil K Maurya
Journal:  RSC Med Chem       Date:  2020-12-23

3.  Transition-metal-free regioselective C-H halogenation of imidazo[1,2-a]pyridines: sodium chlorite/bromite as the halogen source.

Authors:  Junxuan Li; Jiayi Tang; Yuanheng Wu; Qiuxing He; Yue Yu
Journal:  RSC Adv       Date:  2018-02-01       Impact factor: 4.036

4.  Structural characterization and Hirshfeld surface analysis of a CoII complex with imidazo[1,2-a]pyridine.

Authors:  Saikat Kumar Seth
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-04-17

5.  An efficient synthesis of new imidazo[1,2-a]pyridine-6-carbohydrazide and pyrido[1,2-a]pyrimidine-7-carbohydrazide derivatives via a five-component cascade reaction.

Authors:  Hajar Hosseini; Mohammad Bayat
Journal:  RSC Adv       Date:  2019-03-05       Impact factor: 4.036

6.  Synthesis of 5-amino-N'-(9H-fluoren-9-ylidene)-8-nitro-7-aryl-1,2,3,7-tetrahydroimidazo[1,2-a]pyridine-6-carbohydrazide derivatives based on heterocyclic ketene aminals.

Authors:  Hajar Hosseini; Mohammad Bayat
Journal:  RSC Adv       Date:  2018-12-11       Impact factor: 4.036

Review 7.  Status presens of antiviral drugs and strategies: Part II: RNA VIRUSES (EXCEPT RETROVIRUSES).

Authors:  Erik De Clercq
Journal:  Adv Antivir Drug Des       Date:  2007-09-02

8.  Substituted imidazopyridines as potent inhibitors of HCV replication.

Authors:  Inge Vliegen; Jan Paeshuyse; Tine De Burghgraeve; Laura S Lehman; Matthew Paulson; I-Hung Shih; Eric Mabery; Nina Boddeker; Erik De Clercq; Hans Reiser; David Oare; William A Lee; Weidong Zhong; Steven Bondy; Gerhard Pürstinger; Johan Neyts
Journal:  J Hepatol       Date:  2009-02-26       Impact factor: 25.083
  8 in total

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