BACKGROUND: Understanding dengue virus infection in children and the kinetics of maternal dengue neutralizing antibodies is essential for effective dengue immunization of children in endemic areas. METHODS: Serum samples from 219 mother-child pairs and 140 children at 3, 6, 9, 12, 18, and 24 months of age from Bangkok, Thailand, were tested for serotype-specific dengue antibodies. Febrile episodes in the children were recorded. RESULTS: Antibodies were found in 97% of cord serum samples and disappeared in 27%, 80%, and 95% of the children by the age of 6, 9, and 12 months, respectively. Geometric mean titers (GMTs) of the antibodies to 4 dengue serotypes decreased to 5.4-15.5 in 6-month-old infants. Eleven of 12 children acquired dengue virus infection at 6 months of age and beyond; 1 had the infection at 3 months of age. Two exhibited undifferentiated febrile illnesses, and 10 had subclinical infections. CONCLUSIONS: Evidence of dengue virus infection and very low GMTs against all dengue serotypes in children at 6 months of age and beyond was demonstrated. There was no evidence that maternal antibodies were harmful to infants. Dengue virus infection rates increase from 12 months of age onward. These data provide information for supporting the optimal age at vaccination.
BACKGROUND: Understanding dengue virus infection in children and the kinetics of maternal dengue neutralizing antibodies is essential for effective dengue immunization of children in endemic areas. METHODS: Serum samples from 219 mother-child pairs and 140 children at 3, 6, 9, 12, 18, and 24 months of age from Bangkok, Thailand, were tested for serotype-specific dengue antibodies. Febrile episodes in the children were recorded. RESULTS: Antibodies were found in 97% of cord serum samples and disappeared in 27%, 80%, and 95% of the children by the age of 6, 9, and 12 months, respectively. Geometric mean titers (GMTs) of the antibodies to 4 dengue serotypes decreased to 5.4-15.5 in 6-month-old infants. Eleven of 12 children acquired dengue virus infection at 6 months of age and beyond; 1 had the infection at 3 months of age. Two exhibited undifferentiated febrile illnesses, and 10 had subclinical infections. CONCLUSIONS: Evidence of dengue virus infection and very low GMTs against all dengue serotypes in children at 6 months of age and beyond was demonstrated. There was no evidence that maternal antibodies were harmful to infants. Dengue virus infection rates increase from 12 months of age onward. These data provide information for supporting the optimal age at vaccination.
Authors: G William Letson; Pratap Singhasivanon; Eduardo Fernandez; Nihal Abeysinghe; Juan Jose Amador; Harold S Margolis; Robert Edelman Journal: Hum Vaccin Date: 2010-10-01
Authors: Priscila M S Castanha; Cynthia Braga; Marli T Cordeiro; Ariani I Souza; Claudeir D Silva; Celina M T Martelli; Willem G van Panhuis; Eduardo J M Nascimento; Ernesto T A Marques Journal: J Infect Dis Date: 2016-04-07 Impact factor: 5.226
Authors: Willem G van Panhuis; Christine Luxemburger; Krisana Pengsaa; Kriengsak Limkittikul; Arunee Sabchareon; Jean Lang; Anna P Durbin; Derek A T Cummings Journal: Am J Trop Med Hyg Date: 2011-08 Impact factor: 2.345
Authors: Willem G van Panhuis; Robert V Gibbons; Timothy P Endy; Alan L Rothman; Anon Srikiatkhachorn; Ananda Nisalak; Donald S Burke; Derek A T Cummings Journal: J Infect Dis Date: 2010-10-01 Impact factor: 5.226
Authors: Alexandra C Willcox; Matthew H Collins; Ramesh Jadi; Corinna Keeler; Jonathan B Parr; Dieudonné Mumba; Melchior Kashamuka; Antoinette Tshefu; Aravinda M de Silva; Steven R Meshnick Journal: Am J Trop Med Hyg Date: 2018-07-05 Impact factor: 2.345
Authors: Tran Nguyen Bich Chau; Katherine L Anders; Le Bich Lien; Nguyen Thanh Hung; Lu Thi Minh Hieu; Nguyen Minh Tuan; Tran Thi Thuy; Le Thi Phuong; Nguyen Thi Hong Tham; Mai Ngoc Lanh; Jeremy J Farrar; Stephen S Whitehead; Cameron P Simmons Journal: PLoS Negl Trop Dis Date: 2010-04-13
Authors: Anna P Durbin; Sandra V Mayer; Shannan L Rossi; Irma Y Amaya-Larios; Jose Ramos-Castaneda; Eng Eong Ooi; M Jane Cardosa; Jorge L Munoz-Jordan; Robert B Tesh; William B Messer; Scott C Weaver; Nikos Vasilakis Journal: Virology Date: 2013-02-26 Impact factor: 3.616