Literature DB >> 17073468

Long-term stability by lipid coating monodisperse microbubbles formed by a flow-focusing device.

Esra Talu1, Monica M Lozano, Robert L Powell, Paul A Dayton, Marjorie L Longo.   

Abstract

In this letter, the long-term stabilization of monodisperse microbubbles produced by flow focusing is demonstrated using lipid encapsulation. Fluorescence microscopy, high-speed camera imaging, and particle size analysis were used to investigate the roles of lipid phase behavior, dissolution, Ostwald ripening, and coalescence in the stability of microbubbles formed by flow focusing. It was found that these behaviors were controlled through compositional changes with respect to lipid, emulsifier, and viscosity agents. Microbubbles coated with lipid and PEG emulsifier in a viscous solution were found to contain an extremely narrow size distribution (diameter(av) = 51 microm, standard deviation = 4 microm), which was maintained for up to several months.

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Year:  2006        PMID： 17073468      PMCID： PMC1933492          DOI： 10.1021/la062095+

Source DB:  PubMed          Journal:  Langmuir        ISSN： 0743-7463            Impact factor:   3.882


  9 in total

Review 1.  Advances in microbubble technology.

Authors:  D M Skyba; S Kaul
Journal:  Coron Artery Dis       Date:  2000-05       Impact factor: 1.439

2.  Targeted delivery of gas-filled microspheres, contrast agents for ultrasound imaging.

Authors: 
Journal:  Adv Drug Deliv Rev       Date:  1999-04-05       Impact factor: 15.470

3.  Perfectly monodisperse microbubbling by capillary flow focusing.

Authors:  A M Gañán-Calvo; J M Gordillo
Journal:  Phys Rev Lett       Date:  2001-12-11       Impact factor: 9.161

Review 4.  Targeted imaging using ultrasound.

Authors:  Paul A Dayton; Katherine W Ferrara
Journal:  J Magn Reson Imaging       Date:  2002-10       Impact factor: 4.813

5.  Perfectly monodisperse microbubbling by capillary flow focusing: an alternate physical description and universal scaling.

Authors:  Alfonso M Gañán-Calvo
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2004-02-27

6.  Effect of Surfactants on the Film Drainage.

Authors: 
Journal:  J Colloid Interface Sci       Date:  1999-03-15       Impact factor: 8.128

7.  Test of the Epstein-Plesset model for gas microparticle dissolution in aqueous media: effect of surface tension and gas undersaturation in solution.

Authors:  P Brent Duncan; David Needham
Journal:  Langmuir       Date:  2004-03-30       Impact factor: 3.882

Review 8.  Therapeutic applications of lipid-coated microbubbles.

Authors:  Evan C Unger; Thomas Porter; William Culp; Rachel Labell; Terry Matsunaga; Reena Zutshi
Journal:  Adv Drug Deliv Rev       Date:  2004-05-07       Impact factor: 15.470

9.  Surface phase behavior and microstructure of lipid/PEG-emulsifier monolayer-coated microbubbles.

Authors:  Mark A Borden; Gang Pu; Gabriel J Runner; Marjorie L Longo
Journal:  Colloids Surf B Biointerfaces       Date:  2004-06-01       Impact factor: 5.268
  9 in total
  22 in total

1.  On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging.

Authors:  Kanaka Hettiarachchi; Esra Talu; Marjorie L Longo; Paul A Dayton; Abraham P Lee
Journal:  Lab Chip       Date:  2007-03-08       Impact factor: 6.799

2.  Tailoring the size distribution of ultrasound contrast agents: possible method for improving sensitivity in molecular imaging.

Authors:  Esra Talu; Kanaka Hettiarachchi; Shukui Zhao; Robert L Powell; Abraham P Lee; Marjorie L Longo; Paul A Dayton
Journal:  Mol Imaging       Date:  2007 Nov-Dec       Impact factor: 4.488

3.  Novel methods for preparing phospholipid coated microbubbles.

Authors:  K P Pancholi; U Farook; R Moaleji; E Stride; M J Edirisinghe
Journal:  Eur Biophys J       Date:  2007-08-09       Impact factor: 1.733

4.  Maintaining monodispersity in a microbubble population formed by flow-focusing.

Authors:  Esra Talu; Kanaka Hettiarachchi; Robert L Powell; Abraham P Lee; Paul A Dayton; Marjorie L Longo
Journal:  Langmuir       Date:  2008-01-19       Impact factor: 3.882

5.  Preparation of suspensions of phospholipid-coated microbubbles by coaxial electrohydrodynamic atomization.

Authors:  U Farook; E Stride; M J Edirisinghe
Journal:  J R Soc Interface       Date:  2009-03-06       Impact factor: 4.118

6.  Phase-shift perfluorocarbon agents enhance high intensity focused ultrasound thermal delivery with reduced near-field heating.

Authors:  Linsey C Phillips; Connor Puett; Paul S Sheeran; G Wilson Miller; Terry O Matsunaga; Paul A Dayton
Journal:  J Acoust Soc Am       Date:  2013-08       Impact factor: 1.840

7.  A micrometer-sized ultrasound contrast agent with nanometer-scale polygonal patterning surfaces.

Authors:  Zhonghua Teng; Shiping Cao; Wei Li; Li Yang; Wen Shi; Yuegang Wang; Juefei Wu; Jianping Bin
Journal:  J Med Ultrason (2001)       Date:  2014-05-27       Impact factor: 1.314

8.  Liquid Flooded Flow-Focusing Microfluidic Device for in situ Generation of Monodisperse Microbubbles.

Authors:  Ali Haider Dhanaliwala; Johnny L Chen; Shiying Wang; John A Hossack
Journal:  Microfluid Nanofluidics       Date:  2012-10-06       Impact factor: 2.529

Review 9.  A novel technology: microfluidic devices for microbubble ultrasound contrast agent generation.

Authors:  Hangyu Lin; Junfang Chen; Chuanpin Chen
Journal:  Med Biol Eng Comput       Date:  2016-03-25       Impact factor: 2.602

10.  Oxygen delivery using engineered microparticles.

Authors:  Raymond P Seekell; Andrew T Lock; Yifeng Peng; Alexis R Cole; Dorothy A Perry; John N Kheir; Brian D Polizzotti
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-17       Impact factor: 11.205
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