BACKGROUND AND OBJECTIVES: Evaluation of the ductal epithelium of the breast at increased risk for breast cancer is needed to define the carcinogenic pathway, for risk assessment, and to improve selection of women for chemoprevention therapy. We studied the feasibility of combining breast ductal endoscopy with ductal lavage in the high-risk contralateral breast of women with ipsilateral breast cancer for the evaluation of high-risk ducts and acquisition of ductal epithelial cells for analysis. METHODS: Breast ducts were studied by ductal lavage and ductal endoscopy, and epithelial cell content studied cytologically and quantitatively. RESULTS: Twenty-five subjects and 44 ducts, including 22 (50.0%) which did not produce nipple aspirate fluid (NAF), were studied. Cellular atypia was present in five subjects. Ductal endoscopy was performed on 1 or more ducts in 24 subjects. Structural changes were noted in 63.6% of the ducts, most commonly fibrous stranding or bridging. Ductal sampling with endoscopic brush and coil sampling devices provided additional cellular samples of relatively pure ductal epithelial content (> or = 91% purity) in 8/11 subjects. CONCLUSIONS: Breast ductal endoscopy combined with ductal lavage represents a feasible approach for characterizing the ducts and ductal epithelium of the high-risk breast, especially in a research setting. (c) 2006 Wiley-Liss, Inc.
BACKGROUND AND OBJECTIVES: Evaluation of the ductal epithelium of the breast at increased risk for breast cancer is needed to define the carcinogenic pathway, for risk assessment, and to improve selection of women for chemoprevention therapy. We studied the feasibility of combining breast ductal endoscopy with ductal lavage in the high-risk contralateral breast of women with ipsilateral breast cancer for the evaluation of high-risk ducts and acquisition of ductal epithelial cells for analysis. METHODS: Breast ducts were studied by ductal lavage and ductal endoscopy, and epithelial cell content studied cytologically and quantitatively. RESULTS: Twenty-five subjects and 44 ducts, including 22 (50.0%) which did not produce nipple aspirate fluid (NAF), were studied. Cellular atypia was present in five subjects. Ductal endoscopy was performed on 1 or more ducts in 24 subjects. Structural changes were noted in 63.6% of the ducts, most commonly fibrous stranding or bridging. Ductal sampling with endoscopic brush and coil sampling devices provided additional cellular samples of relatively pure ductal epithelial content (> or = 91% purity) in 8/11 subjects. CONCLUSIONS: Breast ductal endoscopy combined with ductal lavage represents a feasible approach for characterizing the ducts and ductal epithelium of the high-risk breast, especially in a research setting. (c) 2006 Wiley-Liss, Inc.
Authors: Amy E Cyr; Julie A Margenthaler; Jill Conway; Antonella L Rastelli; Rosa M Davila; Feng Gao; Jill R Dietz Journal: Ann Surg Oncol Date: 2011-08-17 Impact factor: 5.344
Authors: Lucy Pigati; Sree C S Yaddanapudi; Ravi Iyengar; Dong-Ja Kim; Steven A Hearn; David Danforth; Michelle L Hastings; Dominik M Duelli Journal: PLoS One Date: 2010-10-20 Impact factor: 3.240
Authors: Jennifer T Loud; Anne C M Thiébaut; Andrea D Abati; Armando C Filie; Kathryn Nichols; David Danforth; Ruthann Giusti; Sheila A Prindiville; Mark H Greene Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-03-31 Impact factor: 4.254
Authors: David N Danforth; Andrew C Warner; Darawalee Wangsa; Thomas Ried; Dominik Duelli; Armando C Filie; Sheila A Prindiville Journal: Breast Cancer (Auckl) Date: 2015-06-08
Authors: Laurien Waaijer; Mando D Filipe; Janine Simons; Carmen C van der Pol; Tjeerd de Boorder; Paul J van Diest; Arjen Joost Witkamp Journal: Breast Cancer Date: 2020-07-28 Impact factor: 4.239
Authors: Jennifer T Loud; Ellen Burke Beckjord; Kathryn Nichols; June Peters; Ruthann Giusti; Mark H Greene Journal: BMC Womens Health Date: 2009-07-14 Impact factor: 2.809
Authors: David N Danforth; Armando C Filie; Andrew C Warner; George W Wright; Zhonghe Sun; Thomas Ried; Christine T McGowan; Sheila A Prindiville Journal: Cancer Prev Res (Phila) Date: 2020-08-04