Literature DB >> 17047777

Introduction of single mutation changes arylmalonate decarboxylase to racemase.

Yosuke Terao1, Kenji Miyamoto, Hiromichi Ohta.   

Abstract

The introduction of only one mutation based on the estimated reaction mechanism endowed arylmalonate decarboxylase with a racemase activity, which catalyses racemisation of alpha-arylpropionates.

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Year:  2006        PMID： 17047777     DOI： 10.1039/b607211a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.

Authors:  Sagar D Khare; Yakov Kipnis; Per Greisen; Ryo Takeuchi; Yacov Ashani; Moshe Goldsmith; Yifan Song; Jasmine L Gallaher; Israel Silman; Haim Leader; Joel L Sussman; Barry L Stoddard; Dan S Tawfik; David Baker
Journal:  Nat Chem Biol       Date:  2012-02-05       Impact factor: 15.040

2.  Crystallization and preliminary X-ray diffraction experiments of arylmalonate decarboxylase from Alcaligenes bronchisepticus.

Authors:  Masayoshi Nakasako; Rika Obata; Ryosuke Okubo; Shyuichi Nakayama; Kenji Miyamoto; Hiromichi Ohta
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-06-11

Review 3.  Directed evolution drives the next generation of biocatalysts.

Authors:  Nicholas J Turner
Journal:  Nat Chem Biol       Date:  2009-08       Impact factor: 15.040

Review 4.  Enzyme (re)design: lessons from natural evolution and computation.

Authors:  John A Gerlt; Patricia C Babbitt
Journal:  Curr Opin Chem Biol       Date:  2009-02-23       Impact factor: 8.822

5.  Substitution of Alanine at Position 184 with Glutamic Acid in Escherichia coli PBP5 Ω-Like Loop Introduces a Moderate Cephalosporinase Activity.

Authors:  Debasish Kar; Satya Deo Pandey; Sathi Mallick; Mouparna Dutta; Anindya S Ghosh
Journal:  Protein J       Date:  2018-04       Impact factor: 2.371

Review 6.  Recent advances in rational approaches for enzyme engineering.

Authors:  Kerstin Steiner; Helmut Schwab
Journal:  Comput Struct Biotechnol J       Date:  2012-10-22       Impact factor: 7.271

7.  Ground-State Destabilization by Active-Site Hydrophobicity Controls the Selectivity of a Cofactor-Free Decarboxylase.

Authors:  Michal Biler; Rory M Crean; Anna K Schweiger; Robert Kourist; Shina Caroline Lynn Kamerlin
Journal:  J Am Chem Soc       Date:  2020-11-12       Impact factor: 15.419

8.  Chemoenzymatic Cascade Synthesis of Optically Pure Alkanoic Acids by Using Engineered Arylmalonate Decarboxylase Variants.

Authors:  Junichi Enoki; Carolin Mügge; Dirk Tischler; Kenji Miyamoto; Robert Kourist
Journal:  Chemistry       Date:  2019-03-12       Impact factor: 5.236
  8 in total

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