BACKGROUND: We are interested in identifying susceptibility genes that predispose subjects to attempted suicide. METHODS: We conducted a secondary analysis of genome-wide linkage data from 162 bipolar pedigrees that incorporated attempted suicide as a clinical covariate. RESULTS: The strongest covariate-based linkage signal was seen on 2p12 at marker D2S1777. The logarithm of odds (LOD) score at marker D2S1777 rose from 1.56 to 3.82 after inclusion of the suicide covariate, resulting in significant chromosome-wide empirically derived p-values for the overall linkage finding (p = .01) and for the change in LOD score after the inclusion of the covariate (p = .02). CONCLUSIONS: The finding on chromosome 2 replicates results from two previous studies of attempted suicide in pedigrees with alcohol dependence and in pedigrees with recurrent early-onset depression. Combined, these three studies provide compelling evidence for a locus influencing attempted suicide on 2p12.
BACKGROUND: We are interested in identifying susceptibility genes that predispose subjects to attempted suicide. METHODS: We conducted a secondary analysis of genome-wide linkage data from 162 bipolar pedigrees that incorporated attempted suicide as a clinical covariate. RESULTS: The strongest covariate-based linkage signal was seen on 2p12 at marker D2S1777. The logarithm of odds (LOD) score at marker D2S1777 rose from 1.56 to 3.82 after inclusion of the suicide covariate, resulting in significant chromosome-wide empirically derived p-values for the overall linkage finding (p = .01) and for the change in LOD score after the inclusion of the covariate (p = .02). CONCLUSIONS: The finding on chromosome 2 replicates results from two previous studies of attempted suicide in pedigrees with alcohol dependence and in pedigrees with recurrent early-onset depression. Combined, these three studies provide compelling evidence for a locus influencing attempted suicide on 2p12.
Authors: Sophia C Gaynor; Marie E Breen; Eric T Monson; Kelly de Klerk; Meredith Parsons; Adam P DeLuca; Todd E Scheetz; Peter P Zandi; James B Potash; Virginia L Willour Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2016-08-02 Impact factor: 3.568
Authors: Hwagyu Suh; Byung Dae Lee; Je Min Park; Young Min Lee; Eunsoo Moon; Hee Jeong Jeong; Soo Yeon Kim; Kang Yoon Lee; Young In Chung Journal: Psychiatry Clin Neurosci Date: 2019-02-02 Impact factor: 5.188
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Authors: Danielle M Dick; Jacquelyn Meyers; Fazil Aliev; John Nurnberger; John Kramer; Sam Kuperman; Bernice Porjesz; Jay Tischfield; Howard J Edenberg; Tatiana Foroud; Marc Schuckit; Alison Goate; Victor Hesselbrock; Laura Bierut Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2010-09 Impact factor: 3.568
Authors: Pamela B Mahon; Adrian M Stütz; Fayaz Seifuddin; Yuqing Huo; Fernando S Goes; Dubravka Jancic; Jennifer T Judy; J Raymond Depaulo; Elliot S Gershon; Francis J McMahon; Peter P Zandi; James B Potash; Virginia L Willour Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2010-07 Impact factor: 3.568
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