Literature DB >> 17046248

Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain.

Nadeem Siddiqui1, Surendra N Pandeya, Suroor A Khan, James Stables, Arpana Rana, Mahfuz Alam, Md Faiz Arshad, Mashooq A Bhat.   

Abstract

A series of sulphonamide derivatives (1-11) were synthesized in good yield and evaluated for their possible anticonvulsant activity and neurotoxic study. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Majority of the compounds were active in MES and scPTZ tests. All the compounds were less toxic than the standard drug phenytoin.

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Year:  2006        PMID： 17046248     DOI： 10.1016/j.bmcl.2006.09.053

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  N-(4-Chloro-2-nitro-phen-yl)methane-sulfonamide.

Authors:  Muhammad Zia-Ur-Rehman; Jamil Anwar Choudary; Nosheen Akbar; Islam Ullah Khan; Muhammad Nadeem Arshad
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-09-30

2.  4-Meth-oxy-N-[6-methyl-2,3-dihydro-1,3-benzothia-zol-2-yl-idene]benzene-sulfonamide.

Authors:  Gabriel Navarrete-Vázquez; Hermenegilda Moreno-Diaz; Rafael Villalobos-Molina; Samuel Estrada-Soto; Hugo Tlahuext
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

3.  N-Cyclo-hexyl-4-meth-oxy-benzene-sulfonamide.

Authors:  Muneeb Hayat Khan; Islam Ullah Khan; Muhammad Nadeem Arshad; Shumaila Younas Mughal; Mehmet Akkurt
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-03-15

4.  N-[2-(3,4-Dimeth-oxy-phen-yl)eth-yl]-N-methyl-benzene-sulfonamide.

Authors:  Jasmine P Vennila; D John Thiruvadigal; E Theboral Sugi Kamala; Helen P Kavitha; V Manivannan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-02-29

5.  Synthesis, Computational Studies and Anticonvulsant Activity of Novel Benzothiazole Coupled Sulfonamide Derivatives.

Authors:  Sukhbir L Khokra; Kanika Arora; Shah A Khan; Pawan Kaushik; Reetu Saini; Asif Husain
Journal:  Iran J Pharm Res       Date:  2019       Impact factor: 1.696

6.  Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives.

Authors:  Nadeem Siddiqui; M Shamsher Alam; James P Stables
Journal:  Eur J Med Chem       Date:  2011-03-10       Impact factor: 6.514

Review 7.  Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review.

Authors:  Chuang Zhao; K P Rakesh; L Ravidar; Wan-Yin Fang; Hua-Li Qin
Journal:  Eur J Med Chem       Date:  2018-11-22       Impact factor: 6.514

8.  Synthesis of new pyridines with sulfonamide moiety via a cooperative vinylogous anomeric-based oxidation mechanism in the presence of a novel quinoline-based dendrimer-like ionic liquid.

Authors:  Morteza Torabi; Meysam Yarie; Mohammad Ali Zolfigol; Shamila Rouhani; Shohreh Azizi; Temitope O Olomola; Malik Maaza; Titus A M Msagati
Journal:  RSC Adv       Date:  2021-01-22       Impact factor: 3.361

9.  5-Chloro-2-phenyl-1,3-benzothia-zole.

Authors:  Sammer Yousuf; Shazia Shah; Nida Ambreen; Khalid M Khan; Shakil Ahmed
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-08-31

10.  Design, synthesis and anticonvulsant activity of some new 5,7-dibromoisatin semicarbazone derivatives.

Authors:  Dheeraj Kumar; Vijay Kumar Sharma; Rajeev Kumar; Tejendra Singh; Hariram Singh; Amar Deep Singh; R K Roy
Journal:  EXCLI J       Date:  2013-07-11       Impact factor: 4.068
  10 in total

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