| Literature DB >> 17042780 |
Inês Mollet1, Nuno L Barbosa-Morais, Jorge Andrade, Maria Carmo-Fonseca.
Abstract
U2 snRNP auxiliary factor (U2AF) is an essential heterodimeric splicing factor composed of two subunits, U2AF(65) and U2AF(35). During the past few years, a number of proteins related to both U2AF(65) and U2AF(35) have been discovered. Here, we review the conserved structural features that characterize the U2AF protein families and their evolutionary emergence. We perform a comprehensive database search designed to identify U2AF protein isoforms produced by alternative splicing, and we discuss the potential implications of U2AF protein diversity for splicing regulation.Entities:
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Year: 2006 PMID: 17042780 DOI: 10.1111/j.1742-4658.2006.05502.x
Source DB: PubMed Journal: FEBS J ISSN: 1742-464X Impact factor: 5.542